DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pug and MTHFD1L

DIOPT Version :9

Sequence 1:	NP_001014614.1	Gene:	pug / 41279	FlyBaseID:	FBgn0020385	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	XP_005266964.1	Gene:	MTHFD1L / 25902	HGNCID:	21055	Length:	986	Species:	Homo sapiens

Alignment Length:	913	Identity:	472/913 - (51%)
Similarity:	605/913 - (66%)	Gaps:	60/913 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 REELRNEVTAMSKQLAD--------FVPGLRIVQVGGREDSNVYIRMKIKAATEIGIDAAHVQLP 107
            |:.:..||...||::..        |.|.|.|:|.|   |.|:...:....|.|.|::..|:.||
Human    71 RDSIVREVIQNSKEVLSLLQEKNPAFKPVLAIIQAG---DDNLMQEINQNLAEEAGLNITHICLP 132

  Fly   108 RSITEVELLDKINDLNEDPRVHGIIVQMPLDCDTPIDSHRITDAVSPEKDVDGLHTVNEGRLAIG 172
            ...:|.|::|:|..:|||.||||:.:|:    ...:.|:::.:|:.|||||||:..:|.|:|..|
Human   133 PDSSEAEIIDEILKINEDTRVHGLALQI----SENLFSNKVLNALKPEKDVDGVTDINLGKLVRG 193

  Fly   173 DLGG-FLPCTPWGCLELIRRSGVEIAGARAVVLGRSKIVGTPAAEL-------------LKWANA 223
            |... |:.......:||:.:|||.:.|.:.:|:|..   |:..|.|             ::|
Human   194 DAHECFVSPVAKAVIELLEKSGVNLDGKKILVVGAH---GSLEAALQCLFQRKGSMTMSIQW--- 252

  Fly   224 TVTVCHSKTRNLEEITRSADILVVGIGVAEMVKGSWIKPGAVVIDCGINVKPDASKASGSKLV-- 286
                   |||.|:.....|||:|:|....|.:..:||:||..|::|..:.. ......||..:
Human   253 -------KTRQLQSKLHEADIVVLGSPKPEEIPLTWIQPGTTVLNCSHDFL-SGKVGCGSPRIHF 309

  Fly   287 -GDVDYAEALQVAGHLTPVPGGVGPMTVAMLMKNTVRSAARFLERLAKSQWALQTLPLKPQRPVP 350
             |.::..:.:.:|              .|:.::|.|.|..|:|......:|.|..|.|:|..|||
Human   310 GGLIEEDDVILLA--------------AALRIQNMVSSGRRWLREQQHRRWRLHCLKLQPLSPVP 360

  Fly   351 SDIVIARAQKPKDIAVLAKEIGLEAREVSLYGNKKAKISLSVLERLKDKEVGHYVVVAGMTPTPL 415
            |||.|:|.|.||.:.||||||||.|.|:.:||..|||:.|||||||||:..|.||:|||:|||||
Human   361 SDIEISRGQTPKAVDVLAKEIGLLADEIEIYGKSKAKVRLSVLERLKDQADGKYVLVAGITPTPL 425

  Fly   416 GEGKTTTLMGLVQALGAHKLRNTMAALRQPSQGPTFGIKGGAAGGGYAQVIPMEEFNLHLTGDIH 480
            ||||:|..:||||||.||...|:.|.|||||||||||:|||||||||||||||||||||||||||
Human   426 GEGKSTVTIGLVQALTAHLNVNSFACLRQPSQGPTFGVKGGAAGGGYAQVIPMEEFNLHLTGDIH 490

  Fly   481 AVSAANNLLAAQLDTRIFHENTQKDKALYDRLVPAIKGQRKFSPIQLRRLQKLGITKTDPDTLTA 545
            |::||||||||.:||||.|||||.|||||:||||.:.|.|:||.|||.||:||||.||||.|||.
Human   491 AITAANNLLAAAIDTRILHENTQTDKALYNRLVPLVNGVREFSEIQLARLKKLGINKTDPSTLTE 555

  Fly   546 DEYGPFARLDIDPDTIMWERVVDINDRYLRTITVGQSPTEKGISRETRFSISVASEIMAVLALSR 610
            :|...||||||||.||.|:||:|.|||:||.||:||..||||..|:.:|.|:|||||||||||:.
Human   556 EEVSKFARLDIDPSTITWQRVLDTNDRFLRKITIGQGNTEKGHYRQAQFDIAVASEIMAVLALTD 620

  Fly   611 SLEDMKQRLADMVVAFDKRGKPVTADDLGVTGALAVLLKDALEPNLMQSLEGTPVLVHAGPFANI 675
            ||.|||.||..||||.||.|:|||||||||||||.||:|||::|||||:||||||.|||||||||
Human   621 SLADMKARLGRMVVASDKSGQPVTADDLGVTGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANI 685

  Fly   676 AHGCNSIIADEVGLKLVGKNGFVCTEAGFGSDIGMEKFCNIKCRTSGRKPNAMVLVATVRAIKMH 740
            |||.:|::||::.|||||:.|||.||||||:|||||||.|||||.||..||.:||||||||:|||
Human   686 AHGNSSVLADKIALKLVGEEGFVVTEAGFGADIGMEKFFNIKCRASGLVPNVVVLVATVRALKMH 750

  Fly   741 GGGAPVTPGAPLNKQYTEENLELVQKGLPNLLQHIENGKAFGMPVVVSLNAHSADTPAEHELVKK 805
            |||..||.|.||.|:|||||::||..|..||.:.|:..:.||:||||:||....||.||.:||.:
Human   751 GGGPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQITQLFGVPVVVALNVFKTDTRAEIDLVCE 815

  Fly   806 AALEAGAFAAVVSTHWADGGAGAVQLADAVIKACEQGNQFRLLYDLELPLVDKMNKIATTMYGAG 870
            .|..||||.||...||:.||.|:|.||.||.:|..:.::|:.|||:::|:|||:..||..:|||.
Human   816 LAKRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQVPIVDKIRTIAQAVYGAK 880

  Fly   871 KVVLSPAAEEKVKRLTDAGFGNLPICMSKVSGSFTGDAKIKGAPKGFTLDVEDVYVSAGAGFVVA 935
            .:.|||.|:.|:.|.|..|||||||||:|...|.:.....||.|:.|.|.:.||..|.||||:..
Human   881 DIELSPEAQAKIDRYTQQGFGNLPICMAKTHLSLSHQPDKKGVPRDFILPISDVRASIGAGFIYP 945

  Fly   936 MCG 938
            :.|
Human   946 LVG 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pug	NP_001014614.1	FolD	39..330	CDD:223268	84/303 (28%)
		THF_DHG_CYH	40..159	CDD:279147	37/115 (32%)
		NAD_bind_m-THF_DH_Cyclohyd	154..324	CDD:133448	48/186 (26%)
		FTHFS	350..968	CDD:279592	381/589 (65%)
MTHFD1L	XP_005266964.1	FolD	72..>288	CDD:223268	71/235 (30%)
		THF_DHG_CYH	74..180	CDD:279147	36/112 (32%)
		NAD_bind_m-THF_DH_Cyclohyd_like	193..335	CDD:133451	39/169 (23%)
		PLN02759	352..949	CDD:178359	385/597 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	785	1.000	Domainoid score	I76
eggNOG	1	0.900	-	-		E1_COG2759
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53867
OrthoDB	1	1.010	-	-		D690393at2759
OrthoFinder	1	1.000	-	-		FOG0001266
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100216
Panther	1	1.100	-	-	O	PTHR48099
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X878
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.790