DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pug and SPBC839.16

DIOPT Version :9

Sequence 1:	NP_001014614.1	Gene:	pug / 41279	FlyBaseID:	FBgn0020385	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	NP_595256.1	Gene:	SPBC839.16 / 2541217	PomBaseID:	SPBC839.16	Length:	937	Species:	Schizosaccharomyces pombe

Alignment Length:	945	Identity:	524/945 - (55%)
Similarity:	682/945 - (72%)	Gaps:	25/945 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 AKIISGTAVAKSIREELRNEVTAMSKQLADFVPGLRIVQVGGREDSNVYIRMKIKAATEIGIDAA 102
            |.::.||::|:.:|||||.:::::......|...|:|:|||||||||||:|||.:||.|.||...
pombe     2 ALLLEGTSLARKVREELREQISSIKSVDPYFNVSLKIIQVGGREDSNVYVRMKTRAANEAGISCE 66

  Fly   103 HVQLPRSITEVELLDKINDLNEDPRVHGIIVQMPLDCDTPIDSHRITDAVSPEKDVDGLHTVNEG 167
            ||..|..|||.:||..|...||||.|||||||:||...  |:...||:||:|||||||....|.|
pombe    67 HVNFPEDITEYDLLLAIKGFNEDPTVHGIIVQLPLPAH--INEQIITEAVAPEKDVDGFCETNLG 129

  Fly   168 RLAIGDLGG---FLPCTPWGCLELIRRSGVEIAGARAVVLGRSKIVGTPAAELLKWANATVTVCH 229
            :|...:  |   |..|||.|.:.:::..|:.:.|..|||:|||.|||.|.:.||:.||||||:||
pombe   130 KLTKRE--GQPLFTACTPKGIMCILKHYGINVQGKHAVVIGRSNIVGRPMSILLEKANATVTLCH 192

  Fly   230 SKTRNLEEITRSADILVVGIGVAEMVKGSWIKPGAVVIDCGINVKPDASKASGSKLVGDVDYAEA 294
            |||.::.:|.|:|||:|..||:...||..|:|.|.|.||.|||..|||:|.||.:|.||:|:..|
pombe   193 SKTESIADIVRTADIVVAAIGIPHFVKADWLKKGVVAIDVGINSIPDATKKSGYRLTGDIDFENA 257

  Fly   295 LQVAGHLTPVPGGVGPMTVAMLMKNTVRSAARFLERLAKSQWALQTLPLKPQRPVPSDIVIARAQ 359
            .:||..:|||||.|||||||||::|.|.||.||.:...|.:..|  ||||.|.||||||.|||:|
pombe   258 KEVASAITPVPGSVGPMTVAMLLQNVVESAVRFRKMSRKRKPTL--LPLKLQTPVPSDIEIARSQ 320

  Fly   360 KPKDIAVLAKEIGLEAREVSLYGNKKAKISLSVLERLKDKEVGHYVVVAGMTPTPLGEGKTTTLM 424
            .||:|..||.|||:...|:..||:.|||::|.:|:||..:..||||||.|:||||.||||:|...
pombe   321 TPKNIGDLASEIGIAKSELEFYGSHKAKVNLEILQRLAHRRDGHYVVVTGITPTPFGEGKSTLTA 385

  Fly   425 GLVQAL-GAHKLRNTMAALRQPSQGPTFGIKGGAAGGGYAQVIPMEEFNLHLTGDIHAVSAANNL 488
            |||||| ...||  .:|.:||||||||||||||||||||:|.||||||||||||||||::||.||
pombe   386 GLVQALSNLDKL--AIACVRQPSQGPTFGIKGGAAGGGYSQFIPMEEFNLHLTGDIHAITAATNL 448

  Fly   489 LAAQLDTRIFHENTQKDKALYDRLVPAIKG-QRKFSPIQLRRLQKLGITKTDPDTLTADEYGPFA 552
            |||.:|||:||||||.|.|||.||. .:|| :|:|:|:..|||:||||.||:|:.||.:|...||
pombe   449 LAAAIDTRMFHENTQSDAALYKRLT-LVKGNKREFAPVMFRRLKKLGIDKTNPEELTEEEQRKFA 512

  Fly   553 RLDIDPDTIMWERVVDINDRYLRTITVGQSPTEKGISRETRFSISVASEIMAVLALSRSLEDMKQ 617
            ||||:|.||.|.|.:|:|||:||.||:|::|||||.:|:|.|.:|||||.|:||||:..|:||::
pombe   513 RLDIEPSTISWNRTLDVNDRFLRKITIGENPTEKGFTRQTGFDLSVASECMSVLALATDLKDMRE 577

  Fly   618 RLADMVVAFDKRGKPVTADDLGVTGALAVLLKDALEPNLMQSLEGTPVLVHAGPFANIAHGCNSI 682
            ||..||||.:|.|:|||||||||.|||.||||||::|.|||:|||||.||||||||||:.|.:||
pombe   578 RLGRMVVASNKSGEPVTADDLGVGGALTVLLKDAIKPTLMQTLEGTPALVHAGPFANISIGASSI 642

  Fly   683 IADEVGLKLVG---------KNGFVCTEAGFGSDIGMEKFCNIKCRTSGRKPNAMVLVATVRAIK 738
            :||.:.|||.|         :.|:|.|||||.||||||||.||||||||.||:|:|:||||:|:|
pombe   643 LADRIALKLAGTEVDEDAKKEAGYVVTEAGFASDIGMEKFFNIKCRTSGLKPDAIVIVATVQALK 707

  Fly   739 MHGGGAPVTPGAPLNKQYTEENLELVQKGLPNLLQHIENGKAFGMPVVVSLNAHSADTPAEHELV 803
            :||||.||.||.|:.:.|..|:::||:||..||.:||.|.:.:|:||||::|..|:|:|.|...:
pombe   708 LHGGGPPVGPGKPIPEVYKREDVDLVRKGCANLAKHISNARKYGLPVVVAINKFSSDSPNEISAI 772

  Fly   804 KKAALEAGAFAAVVSTHWADGGAGAVQLADAVIKACEQ-GNQFRLLYDLELPLVDKMNKIATTMY 867
            ::.||.|||..||.|.|||:||.||:.:|.|:|.|||. .::||||||:..|:..|:..||..||
pombe   773 REEALAAGATDAVDSNHWAEGGKGALGVARALINACENVDSEFRLLYDVHEPIEKKIEIIAKEMY 837

  Fly   868 GAGKVVLSPAAEEKVKRLTDAGFGNLPICMSKVSGSFTGDAKIKGAPKGFTLDVEDVYVSAGAGF 932
            ||..:.|||.|:|:::..|..|:.|||||::|...|.:.|..:||||..||:.:.|:.:||||||
pombe   838 GADGIELSPLAKERLETFTKQGYNNLPICIAKTQYSLSHDPDLKGAPTNFTVPIRDMRLSAGAGF 902

  Fly   933 VVAMCGEVTKMPGLPTRPAIYDIDLNTETGEIEGL 967
            :..:...::.:|||||:||.|:||: .|.|:|.||
pombe   903 IYPLAAAISTIPGLPTKPAYYNIDI-AENGDIVGL 936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pug	NP_001014614.1	FolD	39..330	CDD:223268	150/293 (51%)
		THF_DHG_CYH	40..159	CDD:279147	61/118 (52%)
		NAD_bind_m-THF_DH_Cyclohyd	154..324	CDD:133448	89/172 (52%)
		FTHFS	350..968	CDD:279592	364/630 (58%)
SPBC839.16	NP_595256.1	FolD	4..294	CDD:223268	150/293 (51%)
		THF_DHG_CYH	4..121	CDD:279147	61/118 (52%)
		THF_DHG_CYH_C	127..291	CDD:280955	85/165 (52%)
		PLN02759	304..937	CDD:178359	369/637 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	705	1.000	Domainoid score	I10
eggNOG	1	0.900	-	-		E1_COG2759
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55940
Inparanoid	1	1.050	1004	1.000	Inparanoid score	I35
OMA	1	1.010	-	-		QHG53867
OrthoFinder	1	1.000	-	-		FOG0001266
OrthoInspector	1	1.000	-	-		otm47292
orthoMCL	1	0.900	-	-		OOG6_100216
Panther	1	1.100	-	-	LDO	PTHR48099
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R159
SonicParanoid	1	1.000	-	-		X878
TreeFam	1	0.960	-	-
	14	13.860