DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pug and dao-3

DIOPT Version :9

Sequence 1:	NP_001014614.1	Gene:	pug / 41279	FlyBaseID:	FBgn0020385	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	NP_509362.1	Gene:	dao-3 / 181065	WormBaseID:	WBGene00000929	Length:	303	Species:	Caenorhabditis elegans

Alignment Length:	293	Identity:	148/293 - (50%)
Similarity:	191/293 - (65%)	Gaps:	7/293 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 AKIISGTAVAKSIREELRNEVTAMSKQLADFVPGLRIVQVGGREDSNVYIRMKIKAATEIGIDAA 102
            |:|:||...:|.:..::..::....:...:|...|.|||||.|.||||||..|:|.|.|||.|..
Worm     3 AEIVSGLEYSKKVLHDVGQKIAKTREHHPNFHAVLAIVQVGNRSDSNVYINSKLKKAKEIGADGK 67

  Fly   103 HVQLPRSITEVELLDKINDLNEDPRVHGIIVQMPLDCDTPIDSHRITDAVSPEKDVDGLHTVNEG 167
            .::||.:||:.:|..:|..||.|..:.|||:|:||||...||:..:.|.:.|.||||||..:|.|
Worm    68 LIKLPDTITQGDLKREIMALNHDNEIDGIIIQLPLDCKHEIDADSVIDLIDPLKDVDGLTRINAG 132

  Fly   168 RLAIGDL-GGFLPCTPWGCLELIRRSGVE---IAGARAVVLGRSKIVGTPAAELLKWANATVTVC 228
            |||.|:| ....||||:|||.|::::..:   ::|...||||||||||:|||.|..|.:.|||:|
Worm   133 RLARGELQRTIFPCTPFGCLYLVQQATGDANFVSGKEVVVLGRSKIVGSPAAALFLWHHGTVTIC 197

  Fly   229 HSKTRNLEEITRSADILVVGIGVAEMVKGSWIKPGAVVIDCGINVKPDASKASGSKLVGDVDYAE 293
            ||||.||:|....||||:|.||....||..||||||.||||||||..|   .:..|:.||||...
Worm   198 HSKTPNLKEKCLRADILIVAIGRKHFVKADWIKPGAFVIDCGINVGDD---PNSRKIYGDVDTEA 259

  Fly   294 ALQVAGHLTPVPGGVGPMTVAMLMKNTVRSAAR 326
            |.:|||.||||||||||||||||::||...|.|
Worm   260 AKEVAGFLTPVPGGVGPMTVAMLIRNTFEQAKR 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pug	NP_001014614.1	FolD	39..330	CDD:223268	147/292 (50%)
		THF_DHG_CYH	40..159	CDD:279147	48/118 (41%)
		NAD_bind_m-THF_DH_Cyclohyd	154..324	CDD:133448	100/173 (58%)
		FTHFS	350..968	CDD:279592
dao-3	NP_509362.1	FolD	5..294	CDD:223268	147/291 (51%)
		THF_DHG_CYH	5..124	CDD:279147	48/118 (41%)
		NAD_bind_m-THF_DH_Cyclohyd	119..291	CDD:133448	100/174 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163609
Domainoid	1	1.000	177	1.000	Domainoid score	I2150
eggNOG	1	0.900	-	-		E1_COG2759
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100216
Panther	1	1.100	-	-	LDO	PTHR48099
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.740