Protein Alignment pug and K07E3.4

DIOPT Version :9

• Sequence 1: NP_001014614.1
• Gene: pug / 41279
• FlyBaseID: FBgn0020385
• Length: 968
• Species: Drosophila melanogaster
• Sequence 2: NP_509360.1
• Gene: K07E3.4 / 181064
• WormBaseID: WBGene00019492
• Length: 640
• Species: Caenorhabditis elegans
• Alignment Length: 639
• Identity: 380/639 - (59%)
• Similarity: 472/639 - (73%)
• Gaps: 4/639 - (0%)

  Fly   334 SQWALQTLPLKPQRPVPSDIVIARAQKPKDIAVLAKEIGLEAREVSLYGNKKAKISLSVLERLKD 398
            |.|.::.|......||||||.|:|||.||||..:|.|||::..|:.|||.||||:||.:|:||.:
 Worm     2 STWNVEYLKPTLLTPVPSDIAISRAQPPKDIEKVAGEIGIKQEELDLYGRKKAKVSLDILDRLSE 66

  Fly   399 KEVGHYVVVAGMTPTPLGEGKTTTLMGLVQALGAHKLRNTMAALRQPSQGPTFGIKGGAAGGGYA 463
            .:.|.||||||:|||||||||:||.:|||||||||..:...|.:||||||||||||||||||||:
 Worm    67 VKNGKYVVVAGITPTPLGEGKSTTTIGLVQALGAHLHKKVFACVRQPSQGPTFGIKGGAAGGGYS 131

  Fly   464 QVIPMEEFNLHLTGDIHAVSAANNLLAAQLDTRIFHENTQKDKALYDRLVPA-IKGQRKFSPIQL 527
            ||||||||||||||||||::||||||||.:|.|:|||:||...||::||.|. .||.|..|.|||
 Worm   132 QVIPMEEFNLHLTGDIHAITAANNLLAAAIDARMFHESTQATDALFNRLAPKNKKGVRPLSEIQL 196

  Fly   528 RRLQKLGITKT-DPDTLTADEYGPFARLDIDPDTIMWERVVDINDRYLRTITVGQSPTEKGISRE 591
            |||.:|||.:. |.:.|:.::...||||:|||.||.|.||:|.|||:||.|.:|..|.|||.:|.
 Worm   197 RRLDRLGIPRVDDAENLSEEQRVSFARLNIDPATITWNRVMDTNDRFLRKIEIGMGPNEKGHTRT 261

  Fly   592 TRFSISVASEIMAVLALSRSLEDMKQRLADMVVAFDKRGKPVTADDLGVTGALAVLLKDALEPNL 656
            |:|.|:||||:||:|||:.||.||::|:|.:|:..||.|.||||||:||||||.||::|.:.|||
 Worm   262 TQFDITVASELMAILALTTSLADMQERIARIVIGSDKAGNPVTADDIGVTGALTVLMRDTVRPNL 326

  Fly   657 MQSLEGTPVLVHAGPFANIAHGCNSIIADEVGLKLVGKNGFVCTEAGFGSDIGMEKFCNIKCRTS 721
            ||:||||||.||||||||||||.:||:||:|.|||.|.:|||.||||||:|||||||.|||||.|
 Worm   327 MQTLEGTPVFVHAGPFANIAHGQSSILADKVALKLAGPDGFVITEAGFGADIGMEKFFNIKCRYS 391

  Fly   722 GRKPNAMVLVATVRAIKMHGGGAPVTPGAPLNKQYTEENLELVQKGL-PNLLQHIENGKAFGMPV 785
            |.:|:|:||||||||:||||||..|..||||..:|.:||:.||:.|. .||.:.|||...||:||
 Worm   392 GLQPSAVVLVATVRALKMHGGGPSVVAGAPLKHEYLDENIPLVEGGCDSNLRKQIENANKFGIPV 456

  Fly   786 VVSLNAHSADTPAEHELVKKAALEAGAFAAVVSTHWADGGAGAVQLADAVIKACE-QGNQFRLLY 849
            ||.:|..:.||..|.|||...|.|.|||.||||.||:.||||||.||::::.|.. ...||:.||
 Worm   457 VVCVNKFATDTDKELELVCSKAKEYGAFDAVVSEHWSQGGAGAVALANSLVNATTGHPKQFKFLY 521

  Fly   850 DLELPLVDKMNKIATTMYGAGKVVLSPAAEEKVKRLTDAGFGNLPICMSKVSGSFTGDAKIKGAP 914
            :|:|.|.||:..||..:|||..:.||..|::|::|.|..||..|||||:|...|.:.|...||||
 Worm   522 NLDLSLEDKIATIAKEIYGADGIELSDEAKQKLERYTRQGFSKLPICMAKTHLSLSSDPTKKGAP 586

  Fly   915 KGFTLDVEDVYVSAGAGFVVAMCGEVTKMPGLPTRPAIYDIDLNTETGEIEGLF 968
            .||||.:.||..|.||||:..:.||:|.||||.|||..|||.::..|..|:|||
 Worm   587 TGFTLPIRDVRASVGAGFIYPLVGEMTTMPGLNTRPCFYDITIDPVTEIIDGLF 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pug	NP_001014614.1	FolD	39..330	CDD:223268
		THF_DHG_CYH	40..159	CDD:279147
		NAD_bind_m-THF_DH_Cyclohyd	154..324	CDD:133448
		FTHFS	350..968	CDD:279592	373/621 (60%)
K07E3.4	NP_509360.1	PLN02759	13..640	CDD:178359	375/626 (60%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163608
Domainoid	1	1.000	720	1.000	Domainoid score	I42
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55940
Inparanoid	1	1.050	728	1.000	Inparanoid score	I316
Isobase	1	0.950	-	0.875	Normalized mean entropy	S317
OMA	1	1.010	-	-		QHG53867
OrthoDB	1	1.010	-	-		D690393at2759
OrthoFinder	1	1.000	-	-		FOG0001266
OrthoInspector	1	1.000	-	-		oto20804
orthoMCL	1	0.900	-	-		OOG6_100216
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R159
SonicParanoid	1	1.000	-	-		X878
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.790