DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pug and AgaP_AGAP004677

DIOPT Version :9

Sequence 1:	NP_001014614.1	Gene:	pug / 41279	FlyBaseID:	FBgn0020385	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	XP_001687783.1	Gene:	AgaP_AGAP004677 / 1275382	VectorBaseID:	AGAP004677	Length:	408	Species:	Anopheles gambiae

Alignment Length:	314	Identity:	135/314 - (42%)
Similarity:	187/314 - (59%)	Gaps:	21/314 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 AIKMSGAKIISGTAVAKSIREELRNEVTAMSKQLADFVPGLRIVQVGGREDSNVYIRMKIKAATE 96
            |.||  |::|.|..:|:.|:||||.::.....| ....|.|..:.:|....|..|:..|:|||.:
Mosquito   103 ASKM--AQLIDGKQIAREIQEELRKKIETWKAQ-GHRSPQLTAILIGDDPASTTYVNNKMKAAAD 164

  Fly    97 IGIDAAHVQLPRSITEVELLDKINDLNEDPRVHGIIVQMPLDCDTPIDSHRITDAVSPEKDVDGL 161
            :||::...:....|||.:||::|:.||.|..|.||::|:|:  ...||..::.:|||.:|||||.
Mosquito   165 VGIESKTERFGTEITEEQLLERIDQLNNDDAVDGILIQLPV--PNHIDERKVCNAVSCDKDVDGF 227

  Fly   162 HTVNEGRLAIGDLGGFLPCTPWGCLELIRRSGVEIAGARAVVLGRSKIVGTPAAELLK------- 219
            :..|.|||.: |:...:||||.|..|||:|:|:|..|..|||:||||.||.|.|.||.
Mosquito   228 NERNIGRLCL-DMNTLIPCTPLGVQELIKRTGIETFGKNAVVVGRSKNVGMPIAMLLHADGRNDT 291

  Fly   220 -WANATVTVCHSKT--RNLEEITRSADILVVGIGVAEMVKGSWIKPGAVVIDCGINVKPDASKAS 281
             ..:.|||:||..|  :.|:...|:|||:|...||..::....||.||.:||.||....|.|...
Mosquito   292 CAMDCTVTICHRFTPPQELKRFCRTADIIVTATGVPGLITSDMIKEGAAIIDVGITRITDPSTGK 356

  Fly   282 GSKLVGDVDYAEALQVAGHLTPVPGGVGPMTVAMLMKNTVRSAARFLERLAKSQ 335
             .|||||||:.|..:.||.:|||||||||||||||||||:.:|    :.|||.:
Mosquito   357 -KKLVGDVDFEEVRKKAGLITPVPGGVGPMTVAMLMKNTIIAA----KNLAKKR 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pug	NP_001014614.1	FolD	39..330	CDD:223268	128/300 (43%)
		THF_DHG_CYH	40..159	CDD:279147	41/118 (35%)
		NAD_bind_m-THF_DH_Cyclohyd	154..324	CDD:133448	88/179 (49%)
		FTHFS	350..968	CDD:279592
AgaP_AGAP004677	XP_001687783.1	FolD	108..404	CDD:223268	130/304 (43%)
		THF_DHG_CYH	109..225	CDD:279147	41/118 (35%)
		NAD_bind_m-THF_DH_Cyclohyd	221..399	CDD:133448	89/183 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910