DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pug and mthfd2l

DIOPT Version :9

Sequence 1:	NP_001014614.1	Gene:	pug / 41279	FlyBaseID:	FBgn0020385	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	XP_002941814.2	Gene:	mthfd2l / 100497864	XenbaseID:	XB-GENE-6076442	Length:	353	Species:	Xenopus tropicalis

Alignment Length:	305	Identity:	134/305 - (43%)
Similarity:	183/305 - (60%)	Gaps:	19/305 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 SGAKIISGTAVAKSIREELRNEV-TAMSKQLADFVPGLRIVQVGGREDSNVYIRMKIKAATEIGI 99
            |.|.|||||.:||.|:.|::.|| |.:|  |.:..|.|.::.||....|:.|::.||||||.:||
Frog    55 SKATIISGTKLAKEIQREVQKEVETWLS--LGNRRPHLSVILVGDNPASHTYVKNKIKAATSVGI 117

  Fly   100 DAAHVQLPRSITEVELLDKINDLNEDPRVHGIIVQMPLDCDTPIDSHRITDAVSPEKDVDGLHTV 164
            .:..:..|..|:|.||||.|:.|:.|..|.|::||:||  ...|:...|.:||.|||||||.|.|
Frog   118 SSEVILKPSKISEEELLDVISKLSNDSSVSGLLVQLPL--PEHINERAICNAVVPEKDVDGFHIV 180

  Fly   165 NEGRLAIGDLGGFLPCTPWGCLELIRRSGVEIAGARAVVLGRSKIVGTPAAELL--------KWA 221
            |.|||.: |....:|.|.....|:|:|:|:|..|...||.||||.||.|.:.||        ...
Frog   181 NIGRLCL-DQWSIIPATAAAVWEIIKRTGIETFGKNVVVAGRSKNVGMPISMLLHTDGRHERPGG 244

  Fly   222 NATVTVCHSKTRN--LEEITRSADILVVGIGVAEMVKGSWIKPGAVVIDCGINVKPDASKASGSK 284
            :||||:.|..|..  |:..|:.|||::|..|:.:::....||.||.|||.|||...|  ..:|..
Frog   245 DATVTITHRYTPKDLLKSHTQLADIIIVAAGIPKLITSDMIKEGATVIDVGINHIED--PVTGKT 307

  Fly   285 -LVGDVDYAEALQVAGHLTPVPGGVGPMTVAMLMKNTVRSAARFL 328
             :|||||:....:.||.:|||||||||||||||:|||:.:|.:.:
Frog   308 IIVGDVDFEGVKEKAGFITPVPGGVGPMTVAMLLKNTLLAAKKLV 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pug	NP_001014614.1	FolD	39..330	CDD:223268	132/302 (44%)
		THF_DHG_CYH	40..159	CDD:279147	52/119 (44%)
		NAD_bind_m-THF_DH_Cyclohyd	154..324	CDD:133448	83/180 (46%)
		FTHFS	350..968	CDD:279592
mthfd2l	XP_002941814.2	FolD	58..350	CDD:223268	132/298 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910