DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pug and relch

DIOPT Version :9

Sequence 1:	NP_001014614.1	Gene:	pug / 41279	FlyBaseID:	FBgn0020385	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	XP_012819763.1	Gene:	relch / 100145663	XenbaseID:	XB-GENE-985071	Length:	1220	Species:	Xenopus tropicalis

Alignment Length:	895	Identity:	176/895 - (19%)
Similarity:	303/895 - (33%)	Gaps:	295/895 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VGSGEWTAEP--AIKM--SGAKIISGTAVAKSIREEL---RNEVTAMSKQLADFVPGLRIVQ--- 76
            ||..|...||  |:|.  ..:.|....|:.|.:.:::   .||..|:.:|:.:....:..:|
Frog   329 VGVIEGDLEPIQAVKQIAPDSHISQQAAIIKELEDKIILCNNEKAALLEQIGNLERQIESLQKEN 393

  Fly    77 -VGG----------------REDSNVYIRMKIKAATEIGIDAAHVQLPRSITEVELLDKIND--- 121
             ..|                .|:|:.||.::| ..::...:....:||...:|.|.:.::::
Frog   394 SASGVCSAAPPTSDRLQSQTSEESDHYIDIQI-TDSDAKCEGTEERLPFQQSECEPVCQVSEDIP 457

  Fly   122 -------------LNEDPRVHGIIVQMP-------------LDCDTPIDSHRITDAVSPEKDVDG 160
                         |:..|...|:....|             ..|....|| |:...||...|.:
Frog   458 PSPELAKIRKTTLLSAPPSKAGVHFDKPNRKLSPAFHQALLSFCRMSADS-RLGSEVSQIADSE- 520

  Fly   161 LHTVNEGRLAIGDLGGFLP-------------------CTPWGCL---------------ELIRR 191
                 .|.:.:  ||..||                   ||  .||               .||:|
Frog   521 -----NGVMKM--LGRCLPHIVPNVLLAKREELIPLILCT--ACLHPESKERDQLLHILFNLIKR 576

  Fly   192 SGVE---------IAGARAVVLGRSKIVGTPAAELL---------KWANATVTV---CHSKTRNL 235
            ...|         :|.||.|  |.:::    .||||         |:....:.|   |......|
Frog   577 PDDEQRQMILTGCVAFARHV--GPTRV----EAELLPQCWEQINHKYPERRLLVAESCGDLAPYL 635

  Fly   236 EEITRSADIL-----VVGIGVAEMVKGSWIKPGAVVIDCGINVKPDASKASGSKL----VGDVDY 291
            .:..||:.:|     ::....|:||:.:.||...:::  |....|| ..:.|.:|    :||.
Frog   636 PKEIRSSLVLAMLQQMLMEDKADMVREAVIKSLGIIM--GYIDDPD-KYSQGFELLLTALGDP-- 695

  Fly   292 AEALQVAGHLTPVPG-GVGPMTVAMLMKNTVRSAARFLERLAK---------------------- 333
            :|.:..|.|...:|. ....|.:..|..:.:.:....:|:|.|
Frog   696 SERVVSATHQVFLPAYAAWTMELGNLQSHLIPTLLSKIEKLLKEGEHGLDEHKLHMYLSALQSLI 760

  Fly   334 -SQWA--LQTLPL----KPQRPVPSDIVIARAQKP----KDIAVLAKEIGLEAREVSLYGNKKAK 387
             |.:|  ||..|.    |.|..|| .|.:.|..:|    :|:|.:   ||  :||
Frog   761 PSLFATVLQNAPFTSKAKLQGEVP-QIEVTRFPRPVSPLQDVATI---IG--SRE---------- 809

  Fly   388 ISLSVLERLKDKEVGHYVVVAGMTPTPLGEGKT----------TTLMGLVQALGAHKLRNTMAAL 442
             .|:||.:|.|.::.|             ||.|          ..|..|::.:|...:.:| |::
Frog   810 -QLAVLLQLYDYQLEH-------------EGTTGWESLLWVVNQLLPQLIEIVGRITVTST-ASV 859

  Fly   443 RQPSQ-----GPTFG--IKGGAAGGGYAQVIPMEEFNLHLTGDIHAVSAANNLLAAQLDTRIFHE 500
            .:.|:     ..|||  .........:.:::.:.|.|:.        |.|.|.:..:....|:..
Frog   860 HEFSRFFWRLCRTFGKIFTNTKVKPQFQEILRLSEENID--------STAGNGVLTKATVPIYAT 916

  Fly   501 ------NTQKDKALYDRLVPAIKGQRKFSPIQLRRLQKLGITKTDPDTLTADEYGPFARLDIDPD 559
                  |.::|:.|....:..:             :..|.::....|:|.|.    |..|..:|.
Frog   917 GVLTCYNQEEDRKLLVGFLEDV-------------MTMLSLSHAPLDSLKAS----FVELGTNPA 964

  Fly   560 ------TIMWERVVDINDRYLRTITVGQSPTEKGISRETRFSISVASEIMAVLALSRSLEDMKQR 618
                  |::|..||..:.....|.........||:: ||    .||..::..|....|..::..|
Frog   965 YHELLLTVLWYGVVHTSALVRCTAARMFELLVKGVN-ET----LVAQRVVPALITLSSDPEISVR 1024

  Fly   619 LADMVVAFDKRGKPVTADDL--GVTGALAVLLKD-------ALEPNLMQSLEGTPVLVHAGPFAN 674
            :| .|.||....:.||..:|  .|...||..|:|       :|:..::::            |..
Frog  1025 IA-TVPAFGTIMETVTQRELLERVKMQLASFLEDPQYQDQHSLQTEIIRT------------FGR 1076

  Fly   675 IAHGCNSIIADEVGLKLVGKNGFVCTEAGFGS---DIG---MEKFCNIKC 718
            :.........|:..|..:.|..||..:....|   ||.   .|.:..:.|
Frog  1077 VGPNAEPRFRDDFVLPHLHKLSFVNNQQSVDSKRLDIATHLFEAYSALSC 1126

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pug	NP_001014614.1	FolD	39..330	CDD:223268	76/407 (19%)
		THF_DHG_CYH	40..159	CDD:279147	29/170 (17%)
		NAD_bind_m-THF_DH_Cyclohyd	154..324	CDD:133448	48/234 (21%)
		FTHFS	350..968	CDD:279592	82/417 (20%)
relch	XP_012819763.1	HEAT repeat	523..555	CDD:293787	6/35 (17%)
		HEAT repeat	565..595	CDD:293787	6/29 (21%)
		HEAT repeat	604..630	CDD:293787	6/25 (24%)
		HEAT repeat	641..669	CDD:293787	7/27 (26%)
		HEAT repeat	683..724	CDD:293787	10/42 (24%)
		HEAT repeat	735..760	CDD:293787	2/24 (8%)
		HEAT repeat	1008..1036	CDD:293787	7/28 (25%)
		HEAT repeat	1046..1080	CDD:293787	7/45 (16%)
		HEAT repeat	1089..1123	CDD:293787	8/33 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2759
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.860