DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pug and mthfd2

DIOPT Version :9

Sequence 1:	NP_001014614.1	Gene:	pug / 41279	FlyBaseID:	FBgn0020385	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	NP_001002181.1	Gene:	mthfd2 / 100004977	ZFINID:	ZDB-GENE-040704-20	Length:	338	Species:	Danio rerio

Alignment Length:	307	Identity:	134/307 - (43%)
Similarity:	181/307 - (58%)	Gaps:	27/307 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 AKIISGTAVAKSIREELRNE----VTAMSKQLADFVPGLRIVQVGGREDSNVYIRMKIKAATEIG 98
            |.:|||..:|:.||.|.|::    |:|.:::     |.|.:|.||....|:.|:..|.:||.|:|
Zfish    30 AVVISGRKLARQIRNEARDDVEEWVSAGNRR-----PHLSVVLVGDNPASHSYVLNKTRAAAEVG 89

  Fly    99 IDAAHVQLPRSITEVELLDKINDLNEDPRVHGIIVQMPLDCDTPIDSHRITDAVSPEKDVDGLHT 163
            |.:..:..|.:|:|.||||.|..||.|.||.|::||:||  ...||..|:.:||.|.|||||.|.
Zfish    90 ISSETILKPSNISEEELLDLIVKLNSDHRVDGLLVQLPL--PDHIDERRVCNAVCPGKDVDGFHV 152

  Fly   164 VNEGRLAIGDLGGFLPCTPWGCLELIRRSGVEIAGARAVVLGRSKIVGTPAAELL--------KW 220
            ||.||:.: |....||.||||..|:|:|:|:|..|...:|.||||.||.|.|.||        ..
Zfish   153 VNVGRMCL-DQSTMLPATPWGVWEIIKRTGIETLGKNVLVAGRSKNVGMPIAMLLHTDGRHERPG 216

  Fly   221 ANATVTVCHSKT--RNLEEITRSADILVVGIGVAEMVKGSWIKPGAVVIDCGIN--VKPDASKAS 281
            .:||||:.|..|  ..|.:.|:.|||:|...|:..::....||.||.|||.|||  :.|...|
Zfish   217 GDATVTISHRYTPKEQLRQHTKIADIIVAAAGIPNLITADMIKEGAAVIDVGINRILDPMTGK-- 279

  Fly   282 GSKLVGDVDYAEALQVAGHLTPVPGGVGPMTVAMLMKNTVRSAARFL 328
             ::||||||:....:.|..:|||||||||||||||||||:.:|...:
Zfish   280 -NRLVGDVDFEGVRKKASFITPVPGGVGPMTVAMLMKNTIIAAKNMI 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pug	NP_001014614.1	FolD	39..330	CDD:223268	133/306 (43%)
		THF_DHG_CYH	40..159	CDD:279147	49/122 (40%)
		NAD_bind_m-THF_DH_Cyclohyd	154..324	CDD:133448	86/181 (48%)
		FTHFS	350..968	CDD:279592
mthfd2	NP_001002181.1	FolD	32..323	CDD:223268	133/301 (44%)
		THF_DHG_CYH	32..148	CDD:279147	49/122 (40%)
		NAD_bind_m-THF_DH_Cyclohyd	143..322	CDD:133448	86/182 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100216
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810