DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14683 and Mettl15

DIOPT Version :9

Sequence 1:	NP_788632.1	Gene:	CG14683 / 41278	FlyBaseID:	FBgn0037822	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_084066.2	Gene:	Mettl15 / 76894	MGIID:	1924144	Length:	406	Species:	Mus musculus

Alignment Length:	346	Identity:	155/346 - (44%)
Similarity:	209/346 - (60%)	Gaps:	30/346 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 HVPVLCDTAIEYLQPVPGGTYFDMTFGAGGHTRRLLEKCPEAKVYALDRDPLAHQLARDMSESEE 91
            |:||:.|..:..|.|..|..:.|||||:|||||.:|:|.|:..||||||||:|:.:|..:|
Mouse    72 HIPVMVDQVVHCLAPQKGQVFLDMTFGSGGHTRAILQKEPDVMVYALDRDPVAYAIAEQLS---- 132

  Fly    92 FKGRLIP-----LLGKFSDLPKLFKEHGLAKNSVDGMLFDFGCSSMQFDEAVRGFSISRDGPLDM 151
               ||.|     |||:||....|..:.|:...::||:|.|.||||||.|...||||:.:||||||
Mouse   133 ---RLYPTQIQALLGQFSQAEALLMKAGVQPGTIDGILMDLGCSSMQLDAPERGFSLRKDGPLDM 194

  Fly   152 RMDGG-HSGGVTAADVLANVEEGDLVKILRMYGEEKAAKKIARGLVDARNALFKIETTKQLADII 215
            ||||. :....||:||:..:::..|..|||.|||||.|||||..::.||:. :.|..|:|||.|:
Mouse   195 RMDGDRYPDTPTASDVVNALDQQALASILRAYGEEKHAKKIASAIIQARST-YPISRTQQLASIV 258

  Fly   216 ENIMDGG---TRKDKLRRPAHSATKTFQAIRIFVNNELNEINYGMVLANEILRVDGRLVTITFHS 277
            .......   .|||.|:|..|.|||||||:||||||||||:..|:..|.:.|:..||||.::|||
Mouse   259 AGAFPPSAVYARKDLLQRSTHIATKTFQALRIFVNNELNELYAGLRTAEKFLKTGGRLVALSFHS 323

  Fly   278 LEDTIVKRHINGNVLAGAAN---ALPLKYSSHYAIDEPDILESLTKKS------WKQLHRHVIVP 333
            |||.||||.:.|..:....|   ...:|.:|....|:    |:..:.|      |:.:|:.|:.|
Mouse   324 LEDRIVKRFLLGISMTERFNLSIRQKVKQTSQLDSDQ----ETEERHSVRAPLKWELIHKKVLTP 384

  Fly   334 DADEVARNTRSRSAKLRAAVK 354
            :..:|..|.|.||||||||:|
Mouse   385 EDQDVQDNPRGRSAKLRAAIK 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14683	NP_788632.1	PRK00050	26..356	CDD:234597	155/346 (45%)
Mettl15	NP_084066.2	PRK00050	72..406	CDD:234597	155/346 (45%)
Mettl15	NP_084066.2	S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:Q9WZX6	100..102		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838025
Domainoid	1	1.000	263	1.000	Domainoid score	I1914
eggNOG	1	0.900	-	-		E1_COG0275
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12661
Inparanoid	1	1.050	265	1.000	Inparanoid score	I3036
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62492
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005664
OrthoInspector	1	1.000	-	-		oto93450
orthoMCL	1	0.900	-	-		OOG6_101712
Panther	1	1.100	-	-	LDO	PTHR11265
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4657
SonicParanoid	1	1.000	-	-		X4064
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790