DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6465 and pm20d1.1

DIOPT Version :9

Sequence 1:	NP_650004.1	Gene:	CG6465 / 41274	FlyBaseID:	FBgn0037818	Length:	401	Species:	Drosophila melanogaster
Sequence 2:	NP_001032448.1	Gene:	pm20d1.1 / 553216	ZFINID:	ZDB-GENE-051120-102	Length:	515	Species:	Danio rerio

Alignment Length:	479	Identity:	114/479 - (23%)
Similarity:	178/479 - (37%)	Gaps:	107/479 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KWES-------------DEEIQYFREYLRIPSV---HPDPDYAPCVEF---LRRQANLMDLPMKV 50
            :||:             ::.:..|:..::||:|   ..|.:.....||   |||.     .| ||
Zfish    47 QWENTSTIYPYLSPEQREKLLDNFKVAVQIPTVSFSESDQNITALQEFDLLLRRV-----FP-KV 105

  Fly    51 YYPANEQNPVV-----VLTWKGLNPELPSILLNSHMDVVPVFPE-NWTHPPFGA-DIDEEGRIFA 108
            :..:..::.||     :.|..|.:..|...:|.:|:||||.... .|..|||.| :||  |.|:.
Zfish   106 FSSSLVRHEVVGNYSHLFTVVGADAGLEPYMLLAHIDVVPANEAGGWDAPPFSAQEID--GFIYG 168

  Fly   109 RGTQDMKSVGMQHLAAVRALKRSGAKFKRTIHISFVADEEMGGRYGMRPFVPTEDFRALNVGFAM 173
            |||.|.|...|..|.|:..|...|...:||.:|....|||:.|..|....|.....|.:.:.:.:
Zfish   169 RGTIDNKQSVMGILQALEYLLERGYTPRRTFYIGLGHDEEINGEEGAVKIVNLLKSRGVKLLYVL 233

  Fly   174 DEGLASPD-------EQLPLF-YAERAVWRVYFNISGTAGHGSL--------------------L 210
            ||||...|       |...|. .:|:....|..::|...||.|:                    .
Zfish   234 DEGLTIMDGVVDGLNEPAALIGVSEKGQTTVKLSVSTPPGHSSMPPRESSIGILASAVARLEKNR 298

  Fly   211 LPNTAG---EKLNY-------------IVGKMMEFRRSQVQRLQNNPELVIGDVTTINLTKLGGG 259
            :||..|   |:..:             |:..:..|.......|:..|:......||..:|....|
Zfish   299 MPNLFGHGPERATFEHLAHKFGWSYRMIMSNLWLFSSLLSSVLEGQPDTNAFVRTTTAVTMFNSG 363

  Fly   260 VQSNVVPPLLMVCFDCRLALDVDFEEFEANLHKWCADVGGGIEITYEQKQPKVPPTAIDGSNPF- 323
            |:.||:|           |....|..|..:..:....|...||.|...|:.||  ..|:|.:|.
Zfish   364 VKINVMP-----------AHAEAFVNFRIHSSQTVQGVLNRIESTVSDKRVKV--EFINGFDPLP 415

  Fly   324 ----------WLAFKKATDEM--HISIKPQIFTGGTDSRYIRAVGIPALGFSPMNNTP---VLLH 373
                      :...||:..::  .:::.|.|....||||:...:......|:|....|   ...|
Zfish   416 IGSYEDDTFGYQIIKKSVQDIFPQVTVTPGICVANTDSRHYTQLSPDIYRFAPSWYKPGDSARFH 480

  Fly   374 DHDEFIQADIYLRGVQIFQKIISN 397
            ..:|.|....|...|..:.:::.|
Zfish   481 GVNERISIQNYEEIVLFYFQLMQN 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6465	NP_650004.1	Ac-peptdase-euk	1..401	CDD:273850	114/479 (24%)
CG6465	NP_650004.1	M20_AcylaseI_like	8..399	CDD:193524	112/476 (24%)
pm20d1.1	NP_001032448.1	PRK08262	17..506	CDD:236208	114/479 (24%)
pm20d1.1	NP_001032448.1	M20_yscS	67..503	CDD:193549	111/456 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1432382at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2059
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.950