DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6465 and CG17110

DIOPT Version :9

Sequence 1:	NP_650004.1	Gene:	CG6465 / 41274	FlyBaseID:	FBgn0037818	Length:	401	Species:	Drosophila melanogaster
Sequence 2:	NP_001262858.1	Gene:	CG17110 / 42729	FlyBaseID:	FBgn0039050	Length:	402	Species:	Drosophila melanogaster

Alignment Length:	398	Identity:	230/398 - (57%)
Similarity:	305/398 - (76%)	Gaps:	1/398 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TSKWESDEEIQYFREYLRIPSVHPDPDYAPCVEFLRRQANLMDLPMKVYYPANEQNPVVVLTWKG 67
            |.:|::||||..|:|||||||||||.||..|||||:||||.::|.:.|.||.....|||::.|.|
  Fly     5 TEQWKNDEEIIIFQEYLRIPSVHPDVDYTACVEFLKRQANKLNLRVDVVYPVVPSKPVVIMKWLG 69

  Fly    68 LNPELPSILLNSHMDVVPVFPENWTHPPFGADIDEEGRIFARGTQDMKSVGMQHLAAVRALKRSG 132
            .:|||.||:|||||||||||||.|||.||||.||.:|||:|||.|||||||.|::|||||||.||
  Fly    70 KHPELKSIILNSHMDVVPVFPEKWTHEPFGAHIDAQGRIYARGAQDMKSVGCQYMAAVRALKASG 134

  Fly   133 AKFKRTIHISFVADEEMGGRYGMRPFVPTEDFRALNVGFAMDEGLASPDEQLPLFYAERAVWRVY 197
            .:.|||::::||.|||.||..||..||..:.|:|:||||::|||:||.|:..|:|||||.:|::.
  Fly   135 YQPKRTVYLTFVPDEETGGHMGMAEFVKGDYFKAMNVGFSLDEGIASEDDTYPVFYAERTLWQLR 199

  Fly   198 FNISGTAGHGSLLLPNTAGEKLNYIVGKMMEFRRSQVQRLQNNPELVIGDVTTINLTKLGGGVQS 262
            |..|||:||||||..:|||||.::::.|:|:||.:||:.|..:..|..|||||:|||:|.|||||
  Fly   200 FKFSGTSGHGSLLHKSTAGEKFHFVMDKLMKFRETQVKLLAEDSSLQSGDVTTLNLTQLNGGVQS 264

  Fly   263 NVVPPLLMVCFDCRLALDVDFEEFEANLHKWCADVGGGIEITYEQKQPKVPPTAIDGSNPFWLAF 327
            |||||:|...||.|:|::.:.:..|..:.:||.:||||:|:.:..|.|.| .|.||.|||:||.|
  Fly   265 NVVPPVLEATFDIRIAINQNADAMENQIREWCNEVGGGVELDFTLKCPSV-VTKIDDSNPYWLGF 328

  Fly   328 KKATDEMHISIKPQIFTGGTDSRYIRAVGIPALGFSPMNNTPVLLHDHDEFIQADIYLRGVQIFQ 392
            ||..||:.:....::|.|.|||.|:|.||||||||||:||||||||:|||:::||.||.|:|:::
  Fly   329 KKGLDELGLITHTRVFPGATDSFYVRQVGIPALGFSPINNTPVLLHNHDEYLRADTYLHGIQVYR 393

  Fly   393 KIISNIAN 400
            |:|.:||:
  Fly   394 KLIPSIAD 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6465	NP_650004.1	Ac-peptdase-euk	1..401	CDD:273850	230/398 (58%)
CG6465	NP_650004.1	M20_AcylaseI_like	8..399	CDD:193524	226/390 (58%)
CG17110	NP_001262858.1	Ac-peptdase-euk	5..402	CDD:273850	230/398 (58%)
CG17110	NP_001262858.1	M20_AcylaseI_like	10..400	CDD:193524	226/390 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450356
Domainoid	1	1.000	275	1.000	Domainoid score	I418
eggNOG	1	0.900	-	-		E1_COG0624
Homologene	1	1.000	-	-		H110440
Inparanoid	1	1.050	323	1.000	Inparanoid score	I697
Isobase	1	0.950	-	0.854522	Normalized mean entropy	S2324
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001520
OrthoInspector	1	1.000	-	-		otm26566
orthoMCL	1	0.900	-	-		OOG6_100626
Panther	1	1.100	-	-	P	PTHR45892
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2059
SonicParanoid	1	1.000	-	-		X958
	13	12.770