DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6465 and CG6726

DIOPT Version :9

Sequence 1:	NP_650004.1	Gene:	CG6465 / 41274	FlyBaseID:	FBgn0037818	Length:	401	Species:	Drosophila melanogaster
Sequence 2:	NP_001287478.1	Gene:	CG6726 / 42728	FlyBaseID:	FBgn0039049	Length:	401	Species:	Drosophila melanogaster

Alignment Length:	400	Identity:	256/400 - (64%)
Similarity:	319/400 - (79%)	Gaps:	0/400 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MATSKWESDEEIQYFREYLRIPSVHPDPDYAPCVEFLRRQANLMDLPMKVYYPANEQNPVVVLTW 65
            |:|:|||::|||:.||||||||:|||:.||..|.|||:|||..:|||::|.||.|||||||||.|
  Fly     1 MSTAKWENNEEIKIFREYLRIPTVHPNVDYTVCTEFLKRQAASLDLPVEVIYPVNEQNPVVVLKW 65

  Fly    66 KGLNPELPSILLNSHMDVVPVFPENWTHPPFGADIDEEGRIFARGTQDMKSVGMQHLAAVRALKR 130
            :|..||||||:||||.||||||.|.|||.||.||:|.||||||||:||||.||.|:|.||||||.
  Fly    66 QGSQPELPSIILNSHTDVVPVFEEKWTHGPFSADLDAEGRIFARGSQDMKCVGTQYLGAVRALKA 130

  Fly   131 SGAKFKRTIHISFVADEEMGGRYGMRPFVPTEDFRALNVGFAMDEGLASPDEQLPLFYAERAVWR 195
            ||.:.||||::::|.|||:||..|||..|.::.|:.|||||:.|||::|.||...|:||||.:|.
  Fly   131 SGYQPKRTIYLTYVPDEEVGGHLGMRELVKSDYFKKLNVGFSFDEGISSADETYALYYAERTLWH 195

  Fly   196 VYFNISGTAGHGSLLLPNTAGEKLNYIVGKMMEFRRSQVQRLQNNPELVIGDVTTINLTKLGGGV 260
            :.|.||||||||||||||||||||||:||||||||:||||:|.::..|.||||||:|||:|.|||
  Fly   196 LRFKISGTAGHGSLLLPNTAGEKLNYVVGKMMEFRKSQVQKLADDSSLEIGDVTTVNLTQLRGGV 260

  Fly   261 QSNVVPPLLMVCFDCRLALDVDFEEFEANLHKWCADVGGGIEITYEQKQPKVPPTAIDGSNPFWL 325
            |||||||||...||.|:|:.||...||..:..||.:.|||||:.:|.|.|.|.||.||.||.:||
  Fly   261 QSNVVPPLLEAVFDIRIAVTVDIPAFEKQIRDWCEEAGGGIELEFEMKNPFVEPTKIDSSNAYWL 325

  Fly   326 AFKKATDEMHISIKPQIFTGGTDSRYIRAVGIPALGFSPMNNTPVLLHDHDEFIQADIYLRGVQI 390
            |||||.|::.:..:.::|.|.|||||||..|||||||||:||||:||||||||::||.||.|:::
  Fly   326 AFKKALDDLGLKTRVRVFPGATDSRYIRYAGIPALGFSPINNTPILLHDHDEFLKADTYLHGIEV 390

  Fly   391 FQKIISNIAN 400
            ::|:|..:|:
  Fly   391 YKKLIPAVAD 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6465	NP_650004.1	Ac-peptdase-euk	1..401	CDD:273850	256/399 (64%)
CG6465	NP_650004.1	M20_AcylaseI_like	8..399	CDD:193524	250/390 (64%)
CG6726	NP_001287478.1	Ac-peptdase-euk	1..399	CDD:273850	255/397 (64%)
CG6726	NP_001287478.1	M20_AcylaseI_like	8..399	CDD:193524	250/390 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450355
Domainoid	1	1.000	275	1.000	Domainoid score	I418
eggNOG	1	0.900	-	-		E1_COG0624
Homologene	1	1.000	-	-		H110440
Inparanoid	1	1.050	323	1.000	Inparanoid score	I697
Isobase	1	0.950	-	0.854522	Normalized mean entropy	S2324
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001520
OrthoInspector	1	1.000	-	-		otm26566
orthoMCL	1	0.900	-	-		OOG6_100626
Panther	1	1.100	-	-	P	PTHR45892
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2059
SonicParanoid	1	1.000	-	-		X958
	13	12.770