DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6465 and C06A6.4

DIOPT Version :9

Sequence 1:	NP_650004.1	Gene:	CG6465 / 41274	FlyBaseID:	FBgn0037818	Length:	401	Species:	Drosophila melanogaster
Sequence 2:	NP_001021301.1	Gene:	C06A6.4 / 177571	WormBaseID:	WBGene00015509	Length:	411	Species:	Caenorhabditis elegans

Alignment Length:	413	Identity:	176/413 - (42%)
Similarity:	241/413 - (58%)	Gaps:	26/413 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 DEEIQYFREYLRIPSVHPDPDYAPCVEFLRRQANLMDLPMKVYYPANEQNP---VVVLTWKGLNP 70
            |..:..||||||:.:..|.|||..|.:||.:.|:.:.:..:    :.|..|   .|::|..|..|
Worm     4 DIGVTRFREYLRVNTEQPKPDYEACRDFLFKYADELGIERR----SVETAPGTYFVIMTIPGSKP 64

  Fly    71 ELPSILLNSHMDVVPVFPENWTHPPFGADIDEEGRIFARGTQDMKSVGMQHLAAVRALKRSGAK- 134
            :||||:|.||.||||.|.|.|||.|:.|..||:|.|||||.||||.||:|::.|:|.....|.|
Worm    65 DLPSIMLYSHTDVVPTFREYWTHDPYSAFKDEDGNIFARGAQDMKCVGVQYMEALRNWFAKGVKQ 129

  Fly   135 FKRTIHISFVADEEMGGRYGMRPFVPTEDFRALNVGFAMDEGLASPDEQLPLFYAERAVWRVYFN 199
            :.|||||.:..|||:|...||:.|..||:|:.||:.||:|||:|:.|:...:|||||..|.|...
Worm   130 WTRTIHIVWGPDEEIGHINGMKGFAVTEEFKKLNIDFALDEGIATEDDVYKIFYAERIPWWVKVT 194

  Fly   200 ISGTAGHGSLLLPNTAGEKLNYIVGKMMEFRRSQVQRLQNNPELVIGDVTTINLTKLGGGVQSNV 264
            :.|..||||..:..||.|||:.::..:.|||..|...|..:||..:|||||.|:|.:.||||.||
Worm   195 LPGHPGHGSKFIEKTAIEKLHKLIASVDEFRNEQKSLLAEHPEWTVGDVTTSNITIINGGVQVNV 259

  Fly   265 VPPLLMVCFDCRLALDVDFEEFEANLHKWCADVGGGIEITYEQKQPKVP--PTAID--------- 318
            ||.......|.|:....|.:...|.:.:|..:.|.|  :|||..|...|  .:.||
Worm   260 VPEKFEAYIDIRVTPLQDLDAVLARVDQWAKEAGEG--VTYEFMQSTNPADKSTIDFETFSNFKL 322

  Fly   319 -----GSNPFWLAFKKATDEMHISIKPQIFTGGTDSRYIRAVGIPALGFSPMNNTPVLLHDHDEF 378
                 ..:|||.|...|..:.....|.:||.|.||||::||.||.|:||||:.|||.|||||:||
Worm   323 ISPNTREDPFWAAIDDALQKEGCKYKKEIFIGATDSRFVRAQGIRAIGFSPIINTPSLLHDHNEF 387

  Fly   379 IQADIYLRGVQIFQKIISNIANV 401
            :....:||||:|::.:|:.:|||
Worm   388 LNEKTFLRGVEIYETLINKLANV 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6465	NP_650004.1	Ac-peptdase-euk	1..401	CDD:273850	174/411 (42%)
CG6465	NP_650004.1	M20_AcylaseI_like	8..399	CDD:193524	173/409 (42%)
C06A6.4	NP_001021301.1	M20_AcylaseI_like	3..408	CDD:349898	173/409 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160031
Domainoid	1	1.000	290	1.000	Domainoid score	I829
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H110440
Inparanoid	1	1.050	332	1.000	Inparanoid score	I1424
Isobase	1	0.950	-	0.854522	Normalized mean entropy	S2324
OMA	1	1.010	-	-		QHG55259
OrthoDB	1	1.010	-	-		D1432382at2759
OrthoFinder	1	1.000	-	-		FOG0001520
OrthoInspector	1	1.000	-	-		mtm4767
orthoMCL	1	0.900	-	-		OOG6_100626
Panther	1	1.100	-	-	LDO	PTHR45892
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2059
SonicParanoid	1	1.000	-	-		X958
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.890