DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6465 and Acy1

DIOPT Version :9

Sequence 1:	NP_650004.1	Gene:	CG6465 / 41274	FlyBaseID:	FBgn0037818	Length:	401	Species:	Drosophila melanogaster
Sequence 2:	NP_001263371.1	Gene:	Acy1 / 109652	MGIID:	87913	Length:	408	Species:	Mus musculus

Alignment Length:	408	Identity:	205/408 - (50%)
Similarity:	270/408 - (66%)	Gaps:	14/408 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MATSKWESDE-EIQYFREYLRIPSVHPDPDYAPCVEFLRRQANLMDLP-MKVYYPANEQNP---V 60
            |.|...||:. .:..||:||||.:|.|:|||...:.||..:|..:.|. .|:     |..|   :
Mouse     1 MTTKDPESEHPSVTLFRQYLRICTVQPNPDYGGAITFLEERARQLGLSCQKI-----EVVPGFVI 60

  Fly    61 VVLTWKGLNPELPSILLNSHMDVVPVFPENWTHPPFGADIDEEGRIFARGTQDMKSVGMQHLAAV 125
            .||||.|.||.|||||||||.||||||.|:|.|.||.|..|.||.|:|||:||||||.:|:|.||
Mouse    61 TVLTWPGTNPSLPSILLNSHTDVVPVFKEHWHHDPFEAFKDSEGYIYARGSQDMKSVSIQYLEAV 125

  Fly   126 RALKRSGAKFKRTIHISFVADEEMGGRYGMRPFVPTEDFRALNVGFAMDEGLASPDEQLPLFYAE 190
            |.||..|.:|.||||::||.|||:||..||..||...:|:||..||.:|||||:|.:...:||:|
Mouse   126 RRLKSEGHRFPRTIHMTFVPDEEVGGHKGMELFVKRPEFQALRAGFVLDEGLANPTDAFTVFYSE 190

  Fly   191 RAVWRVYFNISGTAGHGSLLLPNTAGEKLNYIVGKMMEFRRSQVQRLQNNPELVIGDVTTINLTK 255
            |:.|.|....:|..||.|..:.:||.|||:.::..::.||..:.||||.||.|..|.||::||||
Mouse   191 RSPWWVQVTSTGKPGHASRFIEDTAAEKLHKVISSILAFREKERQRLQANPHLKEGAVTSVNLTK 255

  Fly   256 LGGGVQSNVVPPLLMVCFDCRLALDVDFEEFEANLHKWCADVGGGIEITYEQK--QPKVPPTAID 318
            |.|||..||||..:...||.|:|.|||.:.||..|.:||.:.|.|:...:.||  :|::.||  |
Mouse   256 LEGGVAYNVVPATMSASFDFRVAPDVDMKAFEKQLQRWCQEAGEGVTFEFAQKFTEPRMTPT--D 318

  Fly   319 GSNPFWLAFKKATDEMHISIKPQIFTGGTDSRYIRAVGIPALGFSPMNNTPVLLHDHDEFIQADI 383
            .|:|:|.||..|...|:::::|:||...||||:|||||||||||||||.||||||||:|.:..||
Mouse   319 DSDPWWAAFSGACKAMNLTLEPEIFPAATDSRFIRAVGIPALGFSPMNRTPVLLHDHNERLHEDI 383

  Fly   384 YLRGVQIFQKIISNIANV 401
            :||||.|:..::|.:|:|
Mouse   384 FLRGVDIYTGLLSALASV 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6465	NP_650004.1	Ac-peptdase-euk	1..401	CDD:273850	204/406 (50%)
CG6465	NP_650004.1	M20_AcylaseI_like	8..399	CDD:193524	200/397 (50%)
Acy1	NP_001263371.1	Ac-peptdase-euk	1..401	CDD:273850	204/406 (50%)
Acy1	NP_001263371.1	M20_AcylaseI_like	9..399	CDD:193524	199/396 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838173
Domainoid	1	1.000	346	1.000	Domainoid score	I1043
eggNOG	1	0.900	-	-		E1_COG0624
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H110440
Inparanoid	1	1.050	396	1.000	Inparanoid score	I1944
Isobase	1	0.950	-	0.854522	Normalized mean entropy	S2324
OMA	1	1.010	-	-		QHG55259
OrthoDB	1	1.010	-	-		D1432382at2759
OrthoFinder	1	1.000	-	-		FOG0001520
OrthoInspector	1	1.000	-	-		otm42915
orthoMCL	1	0.900	-	-		OOG6_100626
Panther	1	1.100	-	-	LDO	PTHR45892
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2059
SonicParanoid	1	1.000	-	-		X958
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750