DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hth and TGIF2LY

DIOPT Version :9

Sequence 1:	NP_476576.1	Gene:	hth / 41273	FlyBaseID:	FBgn0001235	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_631960.1	Gene:	TGIF2LY / 90655	HGNCID:	18569	Length:	185	Species:	Homo sapiens

Alignment Length:	205	Identity:	48/205 - (23%)
Similarity:	76/205 - (37%)	Gaps:	72/205 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 DARSPGAGSTPGPLSQQPPALDTSDPDGKFLSSLNPSELTYDGRWCRREWSSPADARNADASRRL 322
            :|.:.|...|..|:.:..||...|......:.|.|                      |||..|
Human     2 EAAADGPAETQSPVEKDSPAKTQSPAQDTSIMSRN----------------------NADTGR-- 42

  Fly   323 YSSVFLGSPDNFGTSASGDASNASIGSGEGTGEEDDDASGKKNQKKRGIFPKVATNILRAWLFQH 387
                .|..|::                               .:|::|..|..:..|||.|:::|
Human    43 ----VLALPEH-------------------------------KKKRKGNLPAESVKILRDWMYKH 72

  Fly   388 LTHPYPSEDQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVYTPHPGPSGYGHDAMGY 452
            ....||||::|:.|::.|.|::|:::||||||||||:..|:.|..             ....:|:
Human    73 RFKAYPSEEEKQMLSEKTNLSLLRISNWFINARRRILPDMLQQRR-------------NDPIIGH 124

  Fly   453 MMDSQAHMMH 462
            .....||..|
Human   125 KTGKDAHATH 134

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:406806
hth	NP_476576.1	Homeobox_KN	383..422	CDD:399131	18/38 (47%)
TGIF2LY	NP_631960.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58		17/114 (15%)
		Homeobox_KN	68..107	CDD:310480	18/38 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..185
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152641
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840