DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hth and BLH8

DIOPT Version :9

Sequence 1:	NP_476576.1	Gene:	hth / 41273	FlyBaseID:	FBgn0001235	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_180366.1	Gene:	BLH8 / 817343	AraportID:	AT2G27990	Length:	584	Species:	Arabidopsis thaliana

Alignment Length:	523	Identity:	122/523 - (23%)
Similarity:	193/523 - (36%)	Gaps:	135/523 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 AAAAAMYDPHAGHRPPGLQGLPSHHSPHMTHAAAAAATVGMHGYHSGAGGHGTPSHVSPVGNHLM 83
            :||..|..|.:.||.|  || ||:   ......:..:||. |||.. ||       :.|  |::.
plant    64 SAATFMNMPQSIHRDP--QG-PSN---WRISDLSQPSTVN-HGYDQ-AG-------IRP--NNVA 111

  Fly    84 GAIPEVHKRDKDAIYEHPLF------PLLALIFEKCELATCTPREPGVQGGDVCSSESFNEDIAM 142
            ..:.: |...::.|.:.||:      |..::| .:.|::.....:.|..  .|..|.:.||.:..
plant   112 DLLSD-HFSSRNQILDRPLYVGRDSIPQSSMI-RRSEVSCLDDNQKGCV--TVACSGTGNEILRS 172

  Fly   143 FSKQIRSQKPY---YTADPEVDSLMVQAIQVLRFHLLELEKVHELCDNFCH--------RYISCL 196
            ...|..|...|   ::..|.                ||.:.|.....|:.|        .:.:..
plant   173 SYDQGSSSGSYRGEFSFLPS----------------LENQSVAHNASNWNHGPVNVTATSHTNSK 221

  Fly   197 KGKMPIDLVID---ERDTTKPPELGSANGEG--------RSNADSTSHTDGAS----------TP 240
            || .|:.|:.|   .||......|.:.|..|        .|...|:...:.|.          ..
plant   222 KG-FPLSLLSDIPPSRDVGNAAVLSTMNIHGPLGPFTGYASILKSSRFLEPAQKMLEEFCISYAS 285

  Fly   241 DVRPPSSSLSYGGAMNDDARSPGAGSTPGPLS-----QQPPALDTSDPDGKF-----------LS 289
            .:...|.|.|.....:||....|..|:..||.     ::...|...:...|:           :|
plant   286 KIISRSESTSMEDDDDDDDNLSGFSSSSEPLEPKNRLKKAKLLFLQEEVCKWYKLYNHQLQTVMS 350

  Fly   290 SLNPSELTYDGRWCRREWSSPADARNADASRRLYSSVFLGSPDNFGTSASGDASN-------ASI 347
            |.|    |..|......:.|.|..|.:.:.:.|.:::..........|::|:.:|       :.|
plant   351 SFN----TVAGLNTATPYISLALKRTSRSFKALRTAIAEHVKQISSHSSNGNNNNRFQKRQRSLI 411

  Fly   348 GSGEGTGEEDDDASGKKNQKKRGIFPKVATNILRAWLFQHLTHPYPSEDQKKQLAQDTGLTILQV 412
            |:..|...:.....    :.:||: |:.|..:||||||.|..||||::..|:.||..|||:..||
plant   412 GNNVGFESQQQHIW----RPQRGL-PERAVAVLRAWLFDHFLHPYPTDSDKQMLATQTGLSRNQV 471

  Fly   413 NNWFINARRRIVQPMIDQ--------------------SNRAVYTPHP-------GPSGYGHDAM 450
            :|||||||.|:.:||:::                    |||......|       |.||.....:
plant   472 SNWFINARVRLWKPMVEEIHTLETKAIKNADTSHNIEPSNRPNTVSSPSHEQTLTGLSGTKRSRL 536

  Fly   451 GYM 453
            .||
plant   537 EYM 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:406806	19/97 (20%)
hth	NP_476576.1	Homeobox_KN	383..422	CDD:399131	23/38 (61%)
BLH8	NP_180366.1	POX	257..385	CDD:214728	23/131 (18%)
BLH8	NP_180366.1	Homeobox_KN	442..481	CDD:368670	23/38 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	60	1.000	Domainoid score	I3843
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2647
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11850
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X78
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.910