Protein Alignment hth and IRX6

DIOPT Version :9

• Sequence 1: NP_476576.1
• Gene: hth / 41273
• FlyBaseID: FBgn0001235
• Length: 487
• Species: Drosophila melanogaster
• Sequence 2: NP_077311.2
• Gene: IRX6 / 79190
• HGNCID: 14675
• Length: 446
• Species: Homo sapiens
• Alignment Length: 265
• Identity: 64/265 - (24%)
• Similarity: 90/265 - (33%)
• Gaps: 107/265 - (40%)

  Fly   184 LCDNFCHRYISCLKGKMPIDLVIDERDTTKPPELGSANGEGRSNADSTSHTDGASTPDVRPPSSS 248
            ||   |..|.|.|.|             :..||||:|.|
Human    47 LC---CAPYDSRLLG-------------SARPELGAALG-------------------------- 69

  Fly   249 LSYGGAMNDDARSPGAGSTPG--PLSQQPPAL--------DTSDPDGKFLSSLNPSELTYDGRWC 303
             .||...   |.:..|.|.||  |.|.:||:|        :..:..|.|.|||......|
Human    70 -IYGAPY---AAAAAAQSYPGYLPYSPEPPSLYGALNPQYEFKEAAGSFTSSLAQPGAYY----- 125

  Fly   304 RREWSSPADARNADASRRLYSSVFLGSPDNFGTSASGDASNASIGSGEGTGEEDDDASGKKNQKK 368
                  |.:..........|.:|.|        |.:|...||:
Human   126 ------PYERTLGQYQYERYGAVEL--------SGAGRRKNAT---------------------- 154

  Fly   369 RGIFPKVATNILRAWLFQHLTHPYPSEDQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNR 433
                 :..|:.|:|||.:|..:|||::.:|..||..|.:|:.||:.||.|||||     :.:.|:
Human   155 -----RETTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRR-----LKKENK 209

  Fly   434 AVYTP 438
            ..:.|
Human   210 MTWAP 214

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:406806	7/26 (27%)
		Homeobox_KN	383..422	CDD:399131	18/38 (47%)
IRX6	NP_077311.2	Homeobox_KN	164..203	CDD:283551	18/38 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	208..273		2/7 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	362..394

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900