DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hth and Meis1

DIOPT Version :9

Sequence 1:	NP_476576.1	Gene:	hth / 41273	FlyBaseID:	FBgn0001235	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	XP_006251591.1	Gene:	Meis1 / 686117	RGDID:	1585482	Length:	465	Species:	Rattus norvegicus

Alignment Length:	541	Identity:	255/541 - (47%)
Similarity:	291/541 - (53%)	Gaps:	167/541 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAQPRYDDGLHGYGMDSGAAAAAMY-DPHA----------GHRPPGLQGLPSHHSPHMTHAAAAA 54
            ||| ||||..|..|||.....:.|| ||||          .|.||    |.||..||..|..|.|
  Rat     1 MAQ-RYDDLPHYGGMDGVGIPSTMYGDPHAARSMQPVHHLNHGPP----LHSHQYPHTAHTNAMA 60

  Fly    55 ATVGMHGYHSGAGGHGTPSHVSPVGNHLMGAIPEVHKRDKDAIYEHPLFPLLALIFEKCELATCT 119
            .::|                         .::.:..||||||||.||||||||||||||||||||
  Rat    61 PSMG-------------------------SSVNDALKRDKDAIYGHPLFPLLALIFEKCELATCT 100

  Fly   120 PREPGVQGGDVCSSESFNEDIAMFSKQIRSQKPYYTADPEVDSLMVQAIQVLRFHLLELEKVHEL 184
            ||||||.|||||||||||||||:|:||||::||.::::||:|:||:|||||||||||||||||||
  Rat   101 PREPGVAGGDVCSSESFNEDIAVFAKQIRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHEL 165

  Fly   185 CDNFCHRYISCLKGKMPIDLVIDERDTTKPPELGSANGEGRSNADSTSHTDGASTPDVRPPSSSL 249
            |||||||||||||||||||||||:|             ||.|.:||...|..|:..|  .||.:.
  Rat   166 CDNFCHRYISCLKGKMPIDLVIDDR-------------EGGSKSDSEDVTRAANLTD--QPSWNR 215

  Fly   250 SYGGAMNDDARSPGAGSTPGPLSQQPPALDTSDPDGKFLSSLNPSELTYDGRWCRREWSSPADAR 314
            .:     ||..|..:|.||||.|            |...|.
  Rat   216 DH-----DDTASTRSGGTPGPSS------------GGHTSH------------------------ 239

  Fly   315 NADASRRLYSSVFLGSPDNFGTSASGDASNASIGSGEGTGEEDDDASGKKNQKKRGIFPKVATNI 379
                           |.||  :|..||..:.|:.| ..||::||....||..|||||||||||||
  Rat   240 ---------------SGDN--SSEQGDGLDNSVAS-PSTGDDDDPDKDKKRHKKRGIFPKVATNI 286

  Fly   380 LRAWLFQHLTHPYPSEDQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAV-----YTPH 439
            :|||||||||||||||:|||||||||||||||||||||||||||||||||||||||     |.|.
  Rat   287 MRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPD 351

  Fly   440 PGPSGYGHDAMGYMMDSQAHMMHRPP--------------------GDPGFHQ------------ 472
            ..|.|      |::||.|.||..|.|                    |.|.:.|
  Rat   352 GQPMG------GFVMDGQQHMGIRAPGLQSMPGEYVARGGPMGVSMGQPSYTQAQMPPHPAQLRH 410

  Fly   473 ---------GYPHYPPAEYYG 484
                     |:||:|....:|
  Rat   411 GPPMHTYIPGHPHHPAVMMHG 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:406806	70/83 (84%)
hth	NP_476576.1	Homeobox_KN	383..422	CDD:399131	37/38 (97%)
Meis1	XP_006251591.1	Meis_PKNOX_N	108..192	CDD:406806	70/96 (73%)
		Homeobox_KN	290..329	CDD:399131	37/38 (97%)
		PABP-1234	<326..449	CDD:130689	37/112 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346158
Domainoid	1	1.000	157	1.000	Domainoid score	I4060
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H86803
Inparanoid	1	1.050	398	1.000	Inparanoid score	I1879
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1126341at2759
OrthoFinder	1	1.000	-	-		FOG0000410
OrthoInspector	1	1.000	-	-		otm45274
orthoMCL	1	0.900	-	-		OOG6_105229
Panther	1	1.100	-	-	O	PTHR11850
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X78
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.800