DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hth and PKNOX2

DIOPT Version :9

Sequence 1:	NP_476576.1	Gene:	hth / 41273	FlyBaseID:	FBgn0001235	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_001369252.1	Gene:	PKNOX2 / 63876	HGNCID:	16714	Length:	472	Species:	Homo sapiens

Alignment Length:	443	Identity:	158/443 - (35%)
Similarity:	215/443 - (48%)	Gaps:	103/443 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 PPGLQGLPSHHSPHMTHAAAAAATVGMHGYHSGAGGHGTPSHVSPVGNHLMGAIPEVH-KRDKDA 96
            ||     |...||.||..|...:........:.:....||...:|:.       |:.. :.||.|
Human    21 PP-----PYQDSPQMTATAQPPSKAQAVHISAPSAAASTPVPSAPID-------PQAQLEADKRA 73

  Fly    97 IYEHPLFPLLALIFEKCELATCTPREPGVQGGDVCSSESFNEDIAMF-SKQIRSQKPYYTADPEV 160
            :|.|||||||.|:|||||.||        ||.:..:|.||:.||..| .:|.:..||:::.|||:
Human    74 VYRHPLFPLLTLLFEKCEQAT--------QGSECITSASFDVDIENFVHQQEQEHKPFFSDDPEL 130

  Fly   161 DSLMVQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDERDTTKP-----PELGSA 220
            |:|||:||||||.||||||||:|||.:||:|||:|||.||..|.:: ..|...|     |.:...
Human   131 DNLMVKAIQVLRIHLLELEKVNELCKDFCNRYITCLKTKMHSDNLL-RNDLGGPYSPNQPSINLH 194

  Fly   221 NGEGRSNADSTSHTDGASTPDVRPPSSSLSYGG----AMNDDARSPGAGSTPGPLSQQPPALDTS 281
            :.:...|:.::......:...:..|:|:|..|.    .:|....|.||       ..||..:.||
Human   195 SQDLLQNSPNSMSGVSNNPQGIVVPASALQQGNIAMTTVNSQVVSGGA-------LYQPVTMVTS 252

  Fly   282 DPDGKFLSSLNPSELTYDGRWCRREWSSPADARNADASRRLYSSVFLGSPDNFGTSASGDASNAS 346
              .|:.::...|              ......:|...:..|.|.:     ||
Human   253 --QGQVVTQAIP--------------QGAIQIQNTQVNLDLTSLL-----DN------------- 283

  Fly   347 IGSGEGTGEEDDDASGKKNQKKRGIFPKVATNILRAWLFQHLTHPYPSEDQKKQLAQDTGLTILQ 411
                     ||     ||::.|||:.||.||||:|:||||||.||||:||:|:|:|..|.||:||
Human   284 ---------ED-----KKSKNKRGVLPKHATNIMRSWLFQHLMHPYPTEDEKRQIAAQTNLTLLQ 334

  Fly   412 VNNWFINARRRIVQPMIDQSNRAVYTPHPGPSGYGHDAMGYMMDSQAHMMHRP 464
            ||||||||||||:|||:|.||     |.|.|..           .:....|||
Human   335 VNNWFINARRRILQPMLDASN-----PDPAPKA-----------KKIKSQHRP 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:406806	45/84 (54%)
hth	NP_476576.1	Homeobox_KN	383..422	CDD:399131	29/38 (76%)
PKNOX2	NP_001369252.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..62		11/45 (24%)
		gliding_GltG	5..>77	CDD:411344	16/67 (24%)
		Meis_PKNOX_N	96..181	CDD:406806	46/85 (54%)
		Homeobox_KN	306..345	CDD:399131	29/38 (76%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	351..371		7/35 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	386..405
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..472
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152647
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000410
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2315
SonicParanoid	1	1.000	-	-		X78
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.770