Protein Alignment hth and pbx3b

DIOPT Version :10

• Sequence 1: NP_476576.1
• Gene: hth / 41273
• FlyBaseID: FBgn0001235
• Length: 487
• Species: Drosophila melanogaster
• Sequence 2: XP_009302359.1
• Gene: pbx3b / 58140
• ZFINID: ZDB-GENE-000405-3
• Length: 469
• Species: Danio rerio
• Alignment Length: 497
• Identity: 86/497 - (17%)
• Similarity: 143/497 - (28%)
• Gaps: 221/497 - (44%)

  Fly    29 AGHRPPGLQGLPSHHSPHMTHAAAAAATVGMHGYHSGAGGHGTPSHVSPVGNHLM----GAIPEV 89
            |||...|...||..|.                  |.|..|.|....:..:.:.:|    .::.|.
Zfish    17 AGHSVQGGMALPPPHG------------------HDGTDGDGRKQDIGDILHQIMTITDQSLDEA 63

  Fly    90 HKRDKDAIYEHPLFPLLALIFEKCELATCT-----------PREPGVQGGD-------VCSSESF 136
            ..: |..:..|.:.|  ||....||:...|           |.:|.:...|       |...|..
Zfish    64 QAK-KHGLNCHRMKP--ALFSVLCEIKEKTGLSIRGAQEEDPPDPQLMRLDNMLLAEGVAGPEKG 125

  Fly   137 NEDIAMFSKQIRSQKPYYTADPEVD--SLMVQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGK 199
            ....|..:....:..|   .|..::  ....:..|:.:.:..||||..:.|:.|....::.|:
Zfish   126 GGSAAAAAAAAAAGSP---TDNSIEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLR-- 185

  Fly   200 MPIDLVIDERDTTKPPELGSANGEGRSNADSTSHTDGASTPDVRPPSSSLSYGGAMNDDARSPGA 264
                    |:..|:|
Zfish   186 --------EQSRTRP-------------------------------------------------- 192

  Fly   265 GSTPGPLSQQPPALDTSDPDGKFLSSLNPSELTYDGRWCRREWSSPADARNADASRRLYSSV--- 326
                                      ::|.|:                .|......|.:||:
Zfish   193 --------------------------ISPKEI----------------ERMVSIIHRKFSSIQMQ 215

  Fly   327 ---------------FLGSPDNFGTSASGDASNASIGSGEGTGEEDDDASGKKNQKKRGIFPKVA 376
                           ||                              ||     ::||..|.|.|
Zfish   216 LKQSTCEAVMILRSRFL------------------------------DA-----RRKRRNFSKQA 245

  Fly   377 TNILRAWLFQHLTHPYPSEDQKKQLAQ----------DTGLTILQVNNWFINAR---RRIVQPMI 428
            |.||..:.:.||::|||||:.|::||:          .|.:|:.||:|||.|.|   ::.:....
Zfish   246 TEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQGVGTTITVAQVSNWFGNKRIRYKKNIGKFQ 310

  Fly   429 DQSNRAVYTPHPGPSGYGHDAMGYMMDSQAHMMHRPPGDPGF 470
            :::|  :|......:. .|.|...:.:||.:....|  :.||
Zfish   311 EEAN--LYAAKTAVTA-AHAAAAAVQNSQTNSPTTP--NSGF 347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:465140	15/92 (16%)
		Homeobox_KN	384..422	CDD:428673	19/50 (38%)
pbx3b	XP_009302359.1	PBC	44..233	CDD:461052	37/326 (11%)
		homeodomain	235..305	CDD:238039	27/69 (39%)