Protein Alignment hth and pbx2

DIOPT Version :10

• Sequence 1: NP_476576.1
• Gene: hth / 41273
• FlyBaseID: FBgn0001235
• Length: 487
• Species: Drosophila melanogaster
• Sequence 2: XP_017206849.1
• Gene: pbx2 / 58136
• ZFINID: ZDB-GENE-000405-5
• Length: 420
• Species: Danio rerio
• Alignment Length: 515
• Identity: 104/515 - (20%)
• Similarity: 170/515 - (33%)
• Gaps: 214/515 - (41%)

  Fly    27 PHAGHRP-----------PGLQGLPSHHSPHMTHAAAAAATVGMHGYHSGAGGHGTPSHVSPVGN 80
            |..|:.|           ||:..|.|.| |...|....|...|:.|..:   ||.....:..:..
Zfish     7 PITGNGPSASRGGGLSVHPGMHPLNSIH-PAAQHRPDGADPAGLEGTEN---GHDNRRDIGDILQ 67

  Fly    81 HLM----GAIPEVHKRDKDAIYEHPLFPLLALIFEKCELATCTPREPGVQGGDVCSSESFNEDIA 141
            .:|    .::.|...: |.|:..|.:.|  ||....||:                     .|...
Zfish    68 QIMTITDQSLDEAQAK-KHALNCHRMKP--ALFSVLCEI---------------------KEKTG 108

  Fly   142 MFSKQIRSQKPYYTADPEVDSLMVQAIQVLRF-HLLELEKVHELCDNFCHRYISCLKGKMPIDLV 205
            :..:.::.::|   .||          |::|. ::|..|.|
Zfish   109 LSMRNVQEEEP---PDP----------QLVRLDNMLLAEGV------------------------ 136

  Fly   206 IDERDTTKPPELGSANGEGRSNADSTSHTDGASTPDVRPPSSSLSYGGAMNDDARSPGAGSTPGP 270
                       .|...|.|.:.|.|.:.:.|..:||     |||.:     .|.:|        .
Zfish   137 -----------AGPEKGGGAAAAVSAATSSGGMSPD-----SSLEH-----SDYKS--------K 172

  Fly   271 LSQQPPALDTSDPDGKFLSSLNPSELTYDGRWCR----------REWS-----SPAD-ARNADAS 319
            |||              :.::..:||....:.|.          ||.|     ||.: .|.....
Zfish   173 LSQ--------------IRNIYHTELEKYEQACSEFTTHVMNLLREQSRTRPVSPREIERMVAII 223

  Fly   320 RRLYSSV------------------FLGSPDNFGTSASGDASNASIGSGEGTGEEDDDASGKKNQ 366
            .|.:||:                  ||                              ||     :
Zfish   224 HRKFSSIQTQLKQSTCEAVMILRSRFL------------------------------DA-----R 253

  Fly   367 KKRGIFPKVATNILRAWLFQHLTHPYPSEDQKKQLAQDTGLTILQVNNWFINAR---RRIVQPMI 428
            :||..|.|.||.:|..:.:.||::|||||:.|::||:...:|:.||:|||.|.|   ::.:....
Zfish   254 RKRRNFSKQATEVLNEYFYSHLSNPYPSEEAKEELAKQCSITVSQVSNWFGNKRIRYKKNIGKYQ 318

  Fly   429 DQSN-----------RAVYTPH-PGPSGYGHDAMGYMMDSQAHMMHRPP--GD-PGFHQG 473
            :::|           ::..:|| |..:|.|..::....|.   .:..||  |: |.:|.|
Zfish   319 EEANLYAMKTALGATQSEDSPHTPNSTGSGSFSLSGSADC---FLGVPPMNGEQPPYHMG 375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:465140	9/84 (11%)
		Homeobox_KN	384..422	CDD:428673	18/40 (45%)
pbx2	XP_017206849.1	PBC	61..251	CDD:461052	49/323 (15%)
		homeodomain	253..313	CDD:238039	25/59 (42%)