DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hth and irx5a

DIOPT Version :9

Sequence 1:	NP_476576.1	Gene:	hth / 41273	FlyBaseID:	FBgn0001235	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_001038692.1	Gene:	irx5a / 573346	ZFINID:	ZDB-GENE-010716-2	Length:	446	Species:	Danio rerio

Alignment Length:	214	Identity:	57/214 - (26%)
Similarity:	88/214 - (41%)	Gaps:	59/214 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 ADSTSHTDGASTPDVRPPSSSLSYGGAMNDDARSPGAGSTPGPLSQQPPALDTSDPDGKFLSSLN 292
            |.|||...|..|.::         |.:.:..|.:|.||||.                   .:|.:
Zfish    22 AYSTSVISGPRTEEL---------GRSSSGSAFAPYAGSTA-------------------FTSAS 58

  Fly   293 P---SELTYDGRWCRREWSSPADARNADASRRLYSSVFLGSPDNFGTSASGDASNASIGSGEGTG 354
            |   |.|.|                :|||:.....:.::.||.:..|..:|........:..|:.
Zfish    59 PGYNSHLPY----------------SADAAAAATFTSYVSSPYDHTTGMAGSIGYHPYAAPLGSY 107

  Fly   355 EEDDDASGKKNQKKRGIFPKVATNILRAWLFQHLTHPYPSEDQKKQLAQDTGLTILQVNNWFINA 419
            ...|.|. :||..:.      ||..|:|||.:|..:|||::.:|..||..|.:|:.||:.||.||
Zfish   108 PYGDPAY-RKNATRD------ATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANA 165

  Fly   420 RRRIVQPMIDQSNRAVYTP 438
            |||     :.:.|:..:||
Zfish   166 RRR-----LKKENKMTWTP 179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:406806
hth	NP_476576.1	Homeobox_KN	383..422	CDD:399131	18/38 (47%)
irx5a	NP_001038692.1	Homeobox_KN	129..168	CDD:283551	18/38 (47%)
irx5a	NP_001038692.1	IRO	307..324	CDD:214716
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900