DRSC/TRiP Functional Genomics Resources

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Protein Alignment hth and MEIS3

DIOPT Version :9

Sequence 1:NP_476576.1 Gene:hth / 41273 FlyBaseID:FBgn0001235 Length:487 Species:Drosophila melanogaster
Sequence 2:XP_024307380.1 Gene:MEIS3 / 56917 HGNCID:29537 Length:509 Species:Homo sapiens


Alignment Length:553 Identity:218/553 - (39%)
Similarity:263/553 - (47%) Gaps:214/553 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 PRYDDGLHGYGMDSGAAAAAMY--------DPHAGHRPPGLQGLPSHHSPHMTHAAAAAATVGMH 60
            |:||:..|..|:..|.||.|.:        .|:..||||  |.||                    
Human    91 PQYDELPHYPGIVDGPAALASFPETVPAVPGPYGPHRPP--QPLP-------------------- 133

  Fly    61 GYHSGAGGHGTPSHVSPVGNHLMGAIPEVHKRDKDAIYEHPLFPLLALIFEKCELATCTPRE--- 122
               .|....|.                   ||:||.||.|||||||||:|||||||||:||:   
Human   134 ---PGLDSDGL-------------------KREKDEIYGHPLFPLLALVFEKCELATCSPRDGAG 176

  Fly   123 PGV---QGGDVCSSESFNEDIAMFSKQIRSQKPYYTADPEVDSLMVQAIQVLRFHLLELEKVHEL 184
            .|:   .|||||||:|||||||.|:||:||::|.::::||:|:||:|||||||||||||||||:|
Human   177 AGLGTPPGGDVCSSDSFNEDIAAFAKQVRSERPLFSSNPELDNLMIQAIQVLRFHLLELEKVHDL 241

  Fly   185 CDNFCHRYISCLKGKMPIDLVIDERDTTKPPELGSANGEGRSNADSTSHTDGASTPDVRPPSSSL 249
            |||||||||:||||||||||||::||                                       
Human   242 CDNFCHRYITCLKGKMPIDLVIEDRD--------------------------------------- 267

  Fly   250 SYGGAMNDDARSPGAGSTPGPLSQQPPALDTSDPDGKFLSSLNPSELTYDGRWCRREWSSPADAR 314
              ||...|              .:..||...|.||             .:..|.|....|     
Human   268 --GGCRED--------------FEDYPASCPSLPD-------------QNNMWIRDHEDS----- 298

  Fly   315 NADASRRLYSSVFLGSP------------DNFGTSASGDASNASIGSGEGTGEEDDDASGKKNQK 367
                     .||.||:|            ||  :|..||..:.|:.|....||::|....::..|
Human   299 ---------GSVHLGTPGPSSGGLASQSGDN--SSDQGDGLDTSVASPSSGGEDEDLDQERRRNK 352

  Fly   368 KRGIFPKVATNILRAWLFQHLT------------------------------------------- 389
            ||||||||||||:||||||||:                                           
Human   353 KRGIFPKVATNIMRAWLFQHLSRRSEAPVLPDVCLGLGSPSPGPRWARPWGSDCGRPGRQSDSCW 417

  Fly   390 ---HPYPSEDQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNR----AVYTPHPGPSGYGH 447
               ||||||:|||||||||||||||||||||||||||||||||||||    |.::|...|.|   
Human   418 WLQHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRTGQGAAFSPEGQPIG--- 479

  Fly   448 DAMGYMMDSQAHMMHRPPGDPGFH---QGYPHY 477
               || .::|.|:..||||..|..   :|..||
Human   480 ---GY-TETQPHVAVRPPGSVGMSLNLEGEWHY 508

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hthNP_476576.1 Meis_PKNOX_N 127..211 CDD:406806 65/83 (78%)
Homeobox_KN 383..422 CDD:399131 36/84 (43%)
MEIS3XP_024307380.1 Meis_PKNOX_N 184..267 CDD:318653 64/82 (78%)
Homeobox_KN 417..453 CDD:310480 30/35 (86%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165152639
Domainoid 1 1.000 157 1.000 Domainoid score I4145
eggNOG 1 0.900 - - E1_KOG0773
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 397 1.000 Inparanoid score I1961
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1126341at2759
OrthoFinder 1 1.000 - - FOG0000410
OrthoInspector 1 1.000 - - otm41132
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11850
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X78
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.860

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