DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hth and Irx5

DIOPT Version :9

Sequence 1:	NP_476576.1	Gene:	hth / 41273	FlyBaseID:	FBgn0001235	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_061296.1	Gene:	Irx5 / 54352	MGIID:	1859086	Length:	484	Species:	Mus musculus

Alignment Length:	215	Identity:	61/215 - (28%)
Similarity:	87/215 - (40%)	Gaps:	60/215 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 ADSTSHTDGASTPDVRPPSSSLSYGGAMNDDARSPGAGST----PGPLSQQPPALDTSDPDGKFL 288
            |.|||...|..|.::         |.:.:..|.||.||||    |.|
Mouse    22 AYSTSVISGPRTDEL---------GRSSSGSAFSPYAGSTAFTAPSP------------------ 59

  Fly   289 SSLNPSELTYDGRWCRREWSSPADARNADASRRLYSSVFLGSPDNFGTSASGDASNASIGSGEGT 353
             ..| |.|.|.        :.||.|..|..|       ::|||.:.....:|........:..|:
Mouse    60 -GYN-SHLQYG--------ADPAAAAAAAFS-------YVGSPYDHTPGMAGSLGYHPYAAPLGS 107

  Fly   354 GEEDDDASGKKNQKKRGIFPKVATNILRAWLFQHLTHPYPSEDQKKQLAQDTGLTILQVNNWFIN 418
            ....|.|. :||..:.      ||..|:|||.:|..:|||::.:|..||..|.:|:.||:.||.|
Mouse   108 YPYGDPAY-RKNATRD------ATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFAN 165

  Fly   419 ARRRIVQPMIDQSNRAVYTP 438
            ||||     :.:.|:..:||
Mouse   166 ARRR-----LKKENKMTWTP 180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:406806
hth	NP_476576.1	Homeobox_KN	383..422	CDD:399131	18/38 (47%)
Irx5	NP_061296.1	Homeobox_KN	130..169	CDD:283551	18/38 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..393		2/5 (40%)
		IRO	328..345	CDD:214716
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	424..443
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900