DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hth and PBX1

DIOPT Version :9

Sequence 1:	NP_476576.1	Gene:	hth / 41273	FlyBaseID:	FBgn0001235	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	XP_005245285.1	Gene:	PBX1 / 5087	HGNCID:	8632	Length:	486	Species:	Homo sapiens

Alignment Length:	242	Identity:	55/242 - (22%)
Similarity:	80/242 - (33%)	Gaps:	97/242 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   264 AGSTPG-PLSQQP----PALDTSDPDGKFLSSLNPSELTYDGRWCRREWSSPADARNADASRRLY 323
            :.||.| |::.||    |:....  :||.||.....|            ..|.|.:.......|.
Human   119 SASTSGNPVTPQPTHHHPSFGWG--EGKVLSIRGAQE------------EEPTDPQLMRLDNMLL 169

  Fly   324 SSVFLGSPDNFGTSASGDASNASIGSGEGTGEEDDDASGKKNQ---------------------- 366
            :....|.....|::|:..|:.||.|:|.....|..|...|.:|
Human   170 AEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTH 234

  Fly   367 --------------------------------------------------------KKRGIFPKV 375
                                                                    :||..|.|.
Human   235 VMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQ 299

  Fly   376 ATNILRAWLFQHLTHPYPSEDQKKQLAQDTGLTILQVNNWFINARRR 422
            ||.||..:.:.||::|||||:.|::||:..|:|:.||:|||.|.|.|
Human   300 ATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIR 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:406806
hth	NP_476576.1	Homeobox_KN	383..422	CDD:399131	19/38 (50%)
PBX1	XP_005245285.1	PBC	40..288	CDD:281746	27/182 (15%)
PBX1	XP_005245285.1	homeodomain	290..350	CDD:238039	28/57 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152645
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X78
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840