Protein Alignment hth and IRX4

DIOPT Version :9

• Sequence 1: NP_476576.1
• Gene: hth / 41273
• FlyBaseID: FBgn0001235
• Length: 487
• Species: Drosophila melanogaster
• Sequence 2: NP_001265562.1
• Gene: IRX4 / 50805
• HGNCID: 6129
• Length: 545
• Species: Homo sapiens
• Alignment Length: 229
• Identity: 65/229 - (28%)
• Similarity: 91/229 - (39%)
• Gaps: 37/229 - (16%)

  Fly   224 GRSNADSTSHTDGASTPDVRPPSSSLSYGGAMNDDARSPGAGSTPGPL--SQQPPALDTSDPDGK 286
            ||:.||| .....|..|...|...|.....|.::...:...|...||.  ||......|...:..
Human    31 GRTLADS-GPAASAQAPVYCPVYESRLLATARHELNSAAALGVYGGPYGGSQGYGNYVTYGSEAS 94

  Fly   287 FLSSLNPSELTYDGRWCRREWSSPADAR-----------NADASRRLYSSVFLGSP-DNFGTSAS 339
            ...|||..: :.||........:||.|.           ..|..:||.     |.| ...|...|
Human    95 AFYSLNSFD-SKDGSGSAHGGLAPAAAAYYPYEPALGQYPYDRIKRLG-----GHPHKGIGLDLS 153

  Fly   340 GDASNASIGSGEGTGEEDDDASGKKNQKKRGIFPKVATNILRAWLFQHLTHPYPSEDQKKQLAQD 404
            |  ...|.||..||   .|..:.:||..:.      .|:.|:|||.:|..:|||::.:|..||..
Human   154 G--LGRSPGSLYGT---MDSGTRRKNATRE------TTSTLKAWLQEHRKNPYPTKGEKIMLAII 207

  Fly   405 TGLTILQVNNWFINARRRIVQPMIDQSNRAVYTP 438
            |.:|:.||:.||.|||||     :.:.|:..:.|
Human   208 TKMTLTQVSTWFANARRR-----LKKENKMTWPP 236

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:406806
		Homeobox_KN	383..422	CDD:399131	18/38 (47%)
IRX4	NP_001265562.1	Homeobox_KN	186..225	CDD:368670	18/38 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900