DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hth and irx4b

DIOPT Version :9

Sequence 1:	NP_476576.1	Gene:	hth / 41273	FlyBaseID:	FBgn0001235	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_001018329.2	Gene:	irx4b / 474318	ZFINID:	ZDB-GENE-040712-4	Length:	439	Species:	Danio rerio

Alignment Length:	197	Identity:	50/197 - (25%)
Similarity:	76/197 - (38%)	Gaps:	46/197 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   277 ALDTS-DPDGKFLSSLNPSE-------LTYDGRW---CRREWSSPADARNADASRRLYSSVFLGS 330
            ||.|. :..|..|.|..|:.       ..|:.|.   .|.|....|...|:.:...:|.|.....
Zfish    22 ALSTCFESSGSLLDSGVPTSPQNSLYCPVYESRLVASSRHELIPTAVYGNSCSKNHVYDSCSTYG 86

  Fly   331 PDNFGTSASG---DASNASIGSGEGT------------GEEDDDASG---------KKNQKKRGI 371
            ||:......|   :......|....|            |:...|..|         :||..:.
Zfish    87 PDSAACYPLGKLNEKDGVQTGHSRVTQSSAYYPYDYPIGQYSYDRYGYGSVDVGTRRKNATRE-- 149

  Fly   372 FPKVATNILRAWLFQHLTHPYPSEDQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVY 436
                .|:.|:|||.:|..:|||::.:|..||..|.:|:.||:.||.|||||     :.:.|:..:
Zfish   150 ----TTSTLKAWLQEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRR-----LKKENKMTW 205

  Fly   437 TP 438
            :|
Zfish   206 SP 207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:406806
hth	NP_476576.1	Homeobox_KN	383..422	CDD:399131	18/38 (47%)
irx4b	NP_001018329.2	Homeobox_KN	157..196	CDD:283551	18/38 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810