DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hth and MEIS2

DIOPT Version :9

Sequence 1:	NP_476576.1	Gene:	hth / 41273	FlyBaseID:	FBgn0001235	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_733775.1	Gene:	MEIS2 / 4212	HGNCID:	7001	Length:	477	Species:	Homo sapiens

Alignment Length:	510	Identity:	256/510 - (50%)
Similarity:	296/510 - (58%)	Gaps:	128/510 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAQPRYDDGLHGYGMDSGAAAAAMY-DPHAGHRPPGLQGLPSHHSPHMTHAAAAAATVGMHGYHS 64
            ||| |||:..|..|||.....|:|| |||| .||     :|..|  |:.|.....||     .|.
Human     1 MAQ-RYDELPHYGGMDGVGVPASMYGDPHA-PRP-----IPPVH--HLNHGPPLHAT-----QHY 51

  Fly    65 GAGGHGTPSHVSPVGNHLMG-AIPEVHKRDKDAIYEHPLFPLLALIFEKCELATCTPREPGVQGG 128
            ||  |....:|.|..   || |:.:..||||||||.|||||||||:||||||||||||||||.||
Human    52 GA--HAPHPNVMPAS---MGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGG 111

  Fly   129 DVCSSESFNEDIAMFSKQIRSQKPYYTADPEVDSLMVQAIQVLRFHLLELEKVHELCDNFCHRYI 193
            |||||:|||||||:|:||:|::||.::::||:|:||:||||||||||||||||||||||||||||
Human   112 DVCSSDSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYI 176

  Fly   194 SCLKGKMPIDLVIDERDTTKPPELGSANGEGRSNADSTSHTDGAST--PDVRPPSSSLSYGGAMN 256
            |||||||||||||||||           |..:|:.:..|   |:||  .|..|.|      ...:
Human   177 SCLKGKMPIDLVIDERD-----------GSSKSDHEELS---GSSTNLADHNPSS------WRDH 221

  Fly   257 DDARSPGAGSTPGPLSQQPPALDTSDPDGKFLSSLNPSELTYDGRWCRREWSSPADARNADASRR 321
            |||.|..:..||||.|                                          ...||:
Human   222 DDATSTHSAGTPGPSS------------------------------------------GGHASQ- 243

  Fly   322 LYSSVFLGSPDNFGTSASGDASNASIGSGEGTGEEDDDASGKKNQKKRGIFPKVATNILRAWLFQ 386
                    |.||  :|..||..:.|:.| .|||::||....||.||||||||||||||:||||||
Human   244 --------SGDN--SSEQGDGLDNSVAS-PGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQ 297

  Fly   387 HLTHPYPSEDQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNR------------AVYTPH 439
            |||||||||:|||||||||||||||||||||||||||||||||||||            |.|:|.
Human   298 HLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYSPE 362

  Fly   440 PGPSGYGHDAMGYMMDSQAHMMHRP------PGD-------PGFHQGYPHYPPAE 481
            ..|.|      .:::|.|.||..||      |||       .|.....|.|.|.:
Human   363 GQPMG------SFVLDGQQHMGIRPAGLQSMPGDYVSQGGPMGMSMAQPSYTPPQ 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:406806	69/83 (83%)
hth	NP_476576.1	Homeobox_KN	383..422	CDD:399131	37/38 (97%)
MEIS2	NP_733775.1	Required for interaction with PBX1. /evidence=ECO:0000250	71..191		99/119 (83%)
		Meis_PKNOX_N	110..194	CDD:406806	70/94 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	193..283		41/163 (25%)
		Homeobox_KN	294..333	CDD:399131	37/38 (97%)
		Interaction with DNA. /evidence=ECO:0000305\|PubMed:26550823, ECO:0000305\|Ref.16	299..333		32/33 (97%)
		PAT1	<335..>463	CDD:401645	28/83 (34%)
		Transcriptional activation domain	340..477		23/78 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152643
Domainoid	1	1.000	157	1.000	Domainoid score	I4145
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	397	1.000	Inparanoid score	I1961
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1126341at2759
OrthoFinder	1	1.000	-	-		FOG0000410
OrthoInspector	1	1.000	-	-		otm41132
orthoMCL	1	0.900	-	-		OOG6_105229
Panther	1	1.100	-	-	LDO	PTHR11850
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2315
SonicParanoid	1	1.000	-	-		X78
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790