DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hth and Meis3

DIOPT Version :9

Sequence 1:	NP_476576.1	Gene:	hth / 41273	FlyBaseID:	FBgn0001235	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	XP_038937577.1	Gene:	Meis3 / 361514	RGDID:	1308532	Length:	443	Species:	Rattus norvegicus

Alignment Length:	549	Identity:	219/549 - (39%)
Similarity:	267/549 - (48%)	Gaps:	186/549 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RYDDGLHGYGMDSGAAAAAMY-----------DPHAGHRPPGLQGLPSHHSPHMTHAAAAAATVG 58
            ||::..|..|:....||.|.:           .|:..||||..|| |...|..:
  Rat     4 RYEEPRHYPGITEHTAALASFPEAAPSVPRAPGPYGPHRPPQPQG-PGLDSDSL----------- 56

  Fly    59 MHGYHSGAGGHGTPSHVSPVGNHLMGAIPEVHKRDKDAIYEHPLFPLLALIFEKCELATCTPRE- 122
                                            ||:||.||.|||||||||:|||||||||:||:
  Rat    57 --------------------------------KREKDDIYGHPLFPLLALVFEKCELATCSPRDG 89

  Fly   123 --PGV---QGGDVCSSESFNEDIAMFSKQIRSQKPYYTADPEVDSLMVQAIQVLRFHLLELEK-- 180
              .|:   .|||||||:|||||||.|:|||||::|.::::||:|:||||||||||||||||||
  Rat    90 ASAGLGSPPGGDVCSSDSFNEDIAAFAKQIRSERPLFSSNPELDNLMVQAIQVLRFHLLELEKVR 154

  Fly   181 -------------------------------------------------VHELCDNFCHRYISCL 196
                                                             ||:||||||||||:||
  Rat   155 VSHLHLPHPLPLTPLSLLPIGVEAEYSLTLSTPALAPPGGPPSTPLPSQVHDLCDNFCHRYITCL 219

  Fly   197 KGKMPIDLVIDERDTTKPPELGSANGEGRSNADSTSHTDGASTPDVRPPSSSLSYGGAMNDDARS 261
            ||||||||||::||       |....:....|.|.......:|..:|.           ::|:.|
  Rat   220 KGKMPIDLVIEDRD-------GGCREDLEDYAASCPSLPDQNTTWIRD-----------HEDSGS 266

  Fly   262 PGAGSTPGPLSQQPPALDTSDPDGKFLSSLNPSELTYDGRWCRR-EWSSPADARNADASRRLYSS 325
            ...| ||||.|   ..|.:...|       |.|    |..||.. :|.
  Rat   267 VHLG-TPGPSS---GGLASQSGD-------NSS----DQVWCLAVQWG----------------- 299

  Fly   326 VFLGSPDNFGTSASGDASNASIGSGEGTGEEDDDASGKKNQKKRGIFPKVATNILRAWLFQHLTH 390
             ...||        ||..:.|:.|....||::|....::..|||||||||||||:||||||||:|
  Rat   300 -MCPSP--------GDGLDTSVASPSSAGEDEDLDLERRRNKKRGIFPKVATNIMRAWLFQHLSH 355

  Fly   391 PYPSEDQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNR----AVYTPHPGPSGYGHDAMG 451
            |||||:|||||||||||||||||||||||||||||||||||||    |.:.|.      |....|
  Rat   356 PYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRTGQGASFNPE------GQSMAG 414

  Fly   452 YMMDSQAHMMHRPPGDPGFH---QGYPHY 477
            | .::|.|:..|.||..|.:   :|..||
  Rat   415 Y-TETQPHVTVRTPGSMGMNLNLEGEWHY 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:406806	67/134 (50%)
hth	NP_476576.1	Homeobox_KN	383..422	CDD:399131	36/38 (95%)
Meis3	XP_038937577.1	Meis_PKNOX_N	99..234	CDD:406806	68/141 (48%)
Meis3	XP_038937577.1	Homeobox_KN	348..387	CDD:399131	36/38 (95%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346161
Domainoid	1	1.000	157	1.000	Domainoid score	I4060
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	398	1.000	Inparanoid score	I1879
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000410
OrthoInspector	1	1.000	-	-		otm45274
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11850
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X78
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.850