Protein Alignment hth and Pbx3

DIOPT Version :10

• Sequence 1: NP_476576.1
• Gene: hth / 41273
• FlyBaseID: FBgn0001235
• Length: 487
• Species: Drosophila melanogaster
• Sequence 2: NP_001101304.1
• Gene: Pbx3 / 311876
• RGDID: 1307198
• Length: 434
• Species: Rattus norvegicus
• Alignment Length: 499
• Identity: 86/499 - (17%)
• Similarity: 133/499 - (26%)
• Gaps: 258/499 - (51%)

  Fly    29 AGHRPPGLQGLPSHHSPHMTHAAAAAATVGMHGYHSGAGGHGTPSHVSPVGNHLM----GAIPEV 89
            |||...|...||.  .||               .|.||.|.|....:..:.:.:|    .::.|.
  Rat    17 AGHSVQGGMALPP--PPH---------------GHEGADGDGRKQDIGDILHQIMTITDQSLDEA 64

  Fly    90 HKRDKDAIYEHPLFPLLALIFEKCELATCT-----------PREP------------GVQGGD-- 129
            ..: |.|:..|.:.|  ||....||:...|           |.:|            ||.|.:
  Rat    65 QAK-KHALNCHRMKP--ALFSVLCEIKEKTGLSIRGAQEEDPPDPQLMRLDNMLLAEGVSGPEKG 126

  Fly   130 ----------VCSSESFNEDIAMFSKQIRSQKPYYTADPEVDSLMVQAIQVLRFHLLELEKVHEL 184
                      ..|..|.:..|                  |......:..|:.:.:..||||..:.
  Rat   127 GGSAAAAAAAAASGGSSDNSI------------------EHSDYRAKLTQIRQIYHTELEKYEQA 173

  Fly   185 CDNFCHRYISCLKGKMPIDLVIDERDTTKPPELGSANGEGRSNADSTSHTDGASTPDVRPPSSSL 249
            |:.|....::.|:          |:..|:|
  Rat   174 CNEFTTHVMNLLR----------EQSRTRP----------------------------------- 193

  Fly   250 SYGGAMNDDARSPGAGSTPGPLSQQPPALDTSDPDGKFLSSLNPSELTYDGRWCRREWSSPADAR 314
                                                     ::|.|:                .|
  Rat   194 -----------------------------------------ISPKEI----------------ER 201

  Fly   315 NADASRRLYSSV------------------FLGSPDNFGTSASGDASNASIGSGEGTGEEDDDAS 361
            ......|.:||:                  ||                              ||
  Rat   202 MVGIIHRKFSSIQMQLKQSTCEAVMILRSRFL------------------------------DA- 235

  Fly   362 GKKNQKKRGIFPKVATNILRAWLFQHLTHPYPSEDQKKQLAQDTGLTILQVNNWFINARRR---- 422
                ::||..|.|.||.||..:.:.||::|||||:.|::||:...:|:.||:|||.|.|.|
  Rat   236 ----RRKRRNFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKN 296

  Fly   423 ----------------------IVQPMIDQSNRAVYTPHPGPSG 444
                                  :...:.:....:..||:.|.||
  Rat   297 IGKFQEEANLYAAKTAVTAAHAVAAAVQNNQTNSPTTPNSGSSG 340

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:465140	14/95 (15%)
		Homeobox_KN	384..422	CDD:428673	18/37 (49%)
Pbx3	NP_001101304.1	PBC	45..234	CDD:461052	39/341 (11%)
		homeodomain	236..296	CDD:238039	27/59 (46%)