DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hth and Meis2

DIOPT Version :9

Sequence 1:	NP_476576.1	Gene:	hth / 41273	FlyBaseID:	FBgn0001235	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	XP_038960864.1	Gene:	Meis2 / 311311	RGDID:	1305198	Length:	496	Species:	Rattus norvegicus

Alignment Length:	505	Identity:	252/505 - (49%)
Similarity:	292/505 - (57%)	Gaps:	127/505 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 YDDGLHGYGMDSGAAAAAMY-DPHAGHRPPGLQGLPSHHSPHMTHAAAAAATVGMHGYHSGAGGH 69
            ||:..|..|||.....|:|| |||| .||     :|..|  |:.|.....||     .|.||  |
  Rat    24 YDELPHYGGMDGVGVPASMYGDPHA-PRP-----IPPVH--HLNHGPPLHAT-----QHYGA--H 73

  Fly    70 GTPSHVSPVGNHLMG-AIPEVHKRDKDAIYEHPLFPLLALIFEKCELATCTPREPGVQGGDVCSS 133
            ....:|.|..   || |:.:..||||||||.|||||||||:||||||||||||||||.|||||||
  Rat    74 APHPNVMPAS---MGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSS 135

  Fly   134 ESFNEDIAMFSKQIRSQKPYYTADPEVDSLMVQAIQVLRFHLLELEKVHELCDNFCHRYISCLKG 198
            :|||||||:|:||:|::||.::::||:|:||:|||||||||||||||||||||||||||||||||
  Rat   136 DSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKG 200

  Fly   199 KMPIDLVIDERDTTKPPELGSANGEGRSNADSTSHTDGAST--PDVRPPSSSLSYGGAMNDDARS 261
            ||||||||||||           |..:|:.:..|   |:||  .|..|.|      ...:|||.|
  Rat   201 KMPIDLVIDERD-----------GSSKSDHEELS---GSSTNLADHNPSS------WRDHDDATS 245

  Fly   262 PGAGSTPGPLSQQPPALDTSDPDGKFLSSLNPSELTYDGRWCRREWSSPADARNADASRRLYSSV 326
            ..:..||||.|                                          ...||:
  Rat   246 THSAGTPGPSS------------------------------------------GGHASQ------ 262

  Fly   327 FLGSPDNFGTSASGDASNASIGSGEGTGEEDDDASGKKNQKKRGIFPKVATNILRAWLFQHLTHP 391
               |.||  :|..||..:.|:.| .|||::||....||.||||||||||||||:|||||||||||
  Rat   263 ---SGDN--SSEQGDGLDNSVAS-PGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLTHP 321

  Fly   392 YPSEDQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNR------------AVYTPHPGPSG 444
            ||||:|||||||||||||||||||||||||||||||||||||            |.|:|...|.|
  Rat   322 YPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYSPEGQPMG 386

  Fly   445 YGHDAMGYMMDSQAHMMHRP------PGD-------PGFHQGYPHYPPAE 481
                  .:::|.|.||..||      |||       .|.....|.|.|.:
  Rat   387 ------SFVLDGQQHMGIRPAGLQSMPGDYVSQGGPVGMGMAQPSYTPPQ 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:406806	69/83 (83%)
hth	NP_476576.1	Homeobox_KN	383..422	CDD:399131	37/38 (97%)
Meis2	XP_038960864.1	Meis_PKNOX_N	129..213	CDD:406806	70/94 (74%)
		Homeobox_KN	313..352	CDD:399131	37/38 (97%)
		PAT1	<354..>482	CDD:401645	28/83 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346164
Domainoid	1	1.000	157	1.000	Domainoid score	I4060
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	398	1.000	Inparanoid score	I1879
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1126341at2759
OrthoFinder	1	1.000	-	-		FOG0000410
OrthoInspector	1	1.000	-	-		otm45274
orthoMCL	1	0.900	-	-		OOG6_105229
Panther	1	1.100	-	-	LDO	PTHR11850
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X78
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.760