DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hth and MKX

DIOPT Version :9

Sequence 1:	NP_476576.1	Gene:	hth / 41273	FlyBaseID:	FBgn0001235	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_001229631.1	Gene:	MKX / 283078	HGNCID:	23729	Length:	352	Species:	Homo sapiens

Alignment Length:	121	Identity:	37/121 - (30%)
Similarity:	59/121 - (48%)	Gaps:	22/121 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   313 ARNADASRRLYSSVFLGSPDNFGTSASGDASNASIGSGEGTGEEDD----------DASGKKNQK 367
            |...:...|.||.| |.||.          :...:|..:|...:|:          ..:|.|.:.
Human    20 ASERERGGRPYSGV-LDSPH----------ARPEVGIPDGPPLKDNLGLRHRRTGARQNGGKVRH 73

  Fly   368 KRGIFPKVATNILRAWLFQHLTHPYPSEDQKKQLAQDTGLTILQVNNWFINARRRI 423
            ||.....:| ..|:.||::|..:|||::.:|..||..:.:|::||:|||.|||||:
Human    74 KRQALQDMA-RPLKQWLYKHRDNPYPTKTEKILLALGSQMTLVQVSNWFANARRRL 128

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:406806
hth	NP_476576.1	Homeobox_KN	383..422	CDD:399131	18/38 (47%)
MKX	NP_001229631.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	19..54		10/44 (23%)
		Homeobox_KN	88..127	CDD:399131	18/38 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..189
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	245..301
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900