DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hth and Pknox1

DIOPT Version :9

Sequence 1:	NP_476576.1	Gene:	hth / 41273	FlyBaseID:	FBgn0001235	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_057879.2	Gene:	Pknox1 / 18771	MGIID:	1201409	Length:	436	Species:	Mus musculus

Alignment Length:	341	Identity:	138/341 - (40%)
Similarity:	183/341 - (53%)	Gaps:	71/341 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 DKDAIYEHPLFPLLALIFEKCELATCTPREPGVQGGDVCSSESFNEDIAMF-SKQIRSQKPYYTA 156
            ||.|||.|||||||||:|||||.:|        ||.:..:|.||:.||..| .||.:..||::..
Mouse    54 DKQAIYRHPLFPLLALLFEKCEQST--------QGSEGTTSASFDVDIENFVRKQEKDGKPFFCE 110

  Fly   157 DPEVDSLMVQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDERDTTKPPELGSAN 221
            |||.|:|||:||||||.||||||||:|||.:||.|||:|||.||       ..:|....|.||..
Mouse   111 DPETDNLMVKAIQVLRIHLLELEKVNELCKDFCSRYIACLKTKM-------NSETLLSGEPGSPY 168

  Fly   222 GEGRSNADSTSHTDGASTPDVRPPSSSLSYGGAMNDDARSPGAGSTPGPLSQQPPALDTSDPDGK 286
            ...:|....::.|...|...:..|:|:|..|..    ..:..||.|    ..||..:.|  |.|:
Mouse   169 SPVQSQQIQSAITGTLSPQGIVVPASALQQGNV----TMATVAGGT----VYQPVTVVT--PQGQ 223

  Fly   287 FLS-SLNPSELTYDGRWCRREWSSPADARNADASRRLYSSVFLGSPDNFGTSASGDASNASIGSG 350
            .:: :|:|..:.               .:|:....:|...:.:
Mouse   224 VVTQALSPGTIR---------------IQNSQLQLQLNQDLSI---------------------- 251

  Fly   351 EGTGEEDDDASGKKNQKKRGIFPKVATNILRAWLFQHLTHPYPSEDQKKQLAQDTGLTILQVNNW 415
                ...:|.|.|   .|||:.||.|||::|:|||||:.||||:||:|||:|..|.||:||||||
Mouse   252 ----LHQEDGSSK---NKRGVLPKHATNVMRSWLFQHIGHPYPTEDEKKQIAAQTNLTLLQVNNW 309

  Fly   416 FINARRRIVQPMIDQS 431
            ||||||||:|||:|.|
Mouse   310 FINARRRILQPMLDSS 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:406806	45/84 (54%)
hth	NP_476576.1	Homeobox_KN	383..422	CDD:399131	29/38 (76%)
Pknox1	NP_057879.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..50
		Meis_PKNOX_N	80..165	CDD:374576	47/91 (52%)
		Homeobox_KN	277..316	CDD:368670	29/38 (76%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	401..436
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842700
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000410
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X78
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740