DRSC/TRiP Functional Genomics Resources

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Protein Alignment hth and Pbx3

DIOPT Version :10

Sequence 1:NP_476576.1 Gene:hth / 41273 FlyBaseID:FBgn0001235 Length:487 Species:Drosophila melanogaster
Sequence 2:NP_058048.1 Gene:Pbx3 / 18516 MGIID:97496 Length:434 Species:Mus musculus


Alignment Length:484 Identity:88/484 - (18%)
Similarity:136/484 - (28%) Gaps:228/484 - (47%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 AGHRPPGLQGLPSHHSPHMTHAAAAAATVGMHGYHSGAGGHGTPSHVSPVGNHLM----GAIPEV 89
            |||...|...||.  .||               .|.||.|.|....:..:.:.:|    .::.|.
Mouse    17 AGHSVQGGMALPP--PPH---------------GHEGADGDGRKQDIGDILHQIMTITDQSLDEA 64

  Fly    90 HKRDKDAIYEHPLFPLLALIFEKCELATCT-----------PREP------------GVQGGD-- 129
            ..: |.|:..|.:.|  ||....||:...|           |.:|            ||.|.:  
Mouse    65 QAK-KHALNCHRMKP--ALFSVLCEIKEKTGLSIRGAQEEDPPDPQLMRLDNMLLAEGVSGPEKG 126

  Fly   130 ----------VCSSESFNEDIAMFSKQIRSQKPYYTADPEVDSLMVQAIQVLRFHLLELEKVHEL 184
                      ..|..|.:..|                  |......:..|:.:.:..||||..:.
Mouse   127 GGSAAAAAAAAASGGSSDNSI------------------EHSDYRAKLTQIRQIYHTELEKYEQA 173

  Fly   185 CDNFCHRYISCLKGKMPIDLVIDERDTTKPPELGSANGEGRSNADSTSHTDGASTPDVRPPSSSL 249
            |:.|....::.|:          |:..|:|                                   
Mouse   174 CNEFTTHVMNLLR----------EQSRTRP----------------------------------- 193

  Fly   250 SYGGAMNDDARSPGAGSTPGPLSQQPPALDTSDPDGKFLSSLNPSELTYDGRWCRREWSS---PA 311
                                                     ::|.|:........|::||   ..
Mouse   194 -----------------------------------------ISPKEIERMVGIIHRKFSSIQMQL 217

  Fly   312 DARNADASRRLYSSVFLGSPDNFGTSASGDASNASIGSGEGTGEEDDDASGKKNQKKRGIFPKVA 376
            .....:|...|.|. ||                              ||     ::||..|.|.|
Mouse   218 KQSTCEAVMILRSR-FL------------------------------DA-----RRKRRNFSKQA 246

  Fly   377 TNILRAWLFQHLTHPYPSEDQKKQLAQDTGLTILQVNNWFINARRR------------------- 422
            |.||..:.:.||::|||||:.|::||:...:|:.||:|||.|.|.|                   
Mouse   247 TEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKT 311

  Fly   423 -------IVQPMIDQSNRAVYTPHPGPSG 444
                   :...:.:....:..||:.|.||
Mouse   312 AVTAAHAVAAAVQNNQTNSPTTPNSGSSG 340

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hthNP_476576.1 Meis_PKNOX_N 127..211 CDD:465140 14/95 (15%)
Homeobox_KN 384..422 CDD:428673 18/37 (49%)
Pbx3NP_058048.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 20..41 9/37 (24%)
PBC 45..234 CDD:461052 41/326 (13%)
PBC-A. /evidence=ECO:0000255|PROSITE-ProRule:PRU01322 48..127 16/81 (20%)
PBC-B. /evidence=ECO:0000255|PROSITE-ProRule:PRU01322 130..234 25/238 (11%)
homeodomain 236..296 CDD:238039 27/59 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 326..349 5/15 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 405..434
Blue background indicates that the domain is not in the aligned region.

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