Protein Alignment hth and Pbx2

DIOPT Version :9

• Sequence 1: NP_476576.1
• Gene: hth / 41273
• FlyBaseID: FBgn0001235
• Length: 487
• Species: Drosophila melanogaster
• Sequence 2: NP_059491.1
• Gene: Pbx2 / 18515
• MGIID: 1341793
• Length: 430
• Species: Mus musculus
• Alignment Length: 397
• Identity: 79/397 - (19%)
• Similarity: 118/397 - (29%)
• Gaps: 156/397 - (39%)

  Fly   206 IDERDTTKPPELGSANGEGRSNADSTSHTDGASTPDVRPPSSSLSYGGAMNDDARSPGAGS--TP 268
            :|||....||..|...|.|...|:.....:        ||      ||.      .||.||  .|
Mouse     1 MDERLLGPPPPGGGRGGLGLVGAEPGGPGE--------PP------GGG------DPGGGSGGVP 45

  Fly   269 GPLSQQPPALDTSDPDGKFLS----SLNPSELTYDGRWCRR-----------------------E 306
            |...:|    |..|...:.::    ||:.::.......|.|                       :
Mouse    46 GGRGKQ----DIGDILQQIMTITDQSLDEAQAKKHALNCHRMKPALFSVLCEIKEKTGLSIRSSQ 106

  Fly   307 WSSPADARNADASRRLYSSVFLGSPDNFGTSASGDASNASIGSGEGTGE--EDDDASGKKNQ--- 366
            ...|.|.:.......|.:....| |:..|.||:..|:.|:.|.|.....  |..|...|..|
Mouse   107 EEEPVDPQLMRLDNMLLAEGVAG-PEKGGGSAAAAAAAAASGGGVSPDNSIEHSDYRSKLAQIRH 170

  Fly   367 ----------------------------------------------------------------- 366
                                                                             
Mouse   171 IYHSELEKYEQACNEFTTHVMNLLREQSRTRPVAPKEMERMVSIIHRKFSAIQMQLKQSTCEAVM 235

  Fly   367 ----------KKRGIFPKVATNILRAWLFQHLTHPYPSEDQKKQLAQDTGLTILQVNNWFINAR- 420
                      :||..|.|.||.:|..:.:.||::|||||:.|::||:..|:|:.||:|||.|.|
Mouse   236 ILRSRFLDARRKRRNFSKQATEVLNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRI 300

  Fly   421 --RRIVQPMIDQSNRAVY---------------TPHPGPSGYGHDAMGYMMDSQAHMMHRPPGDP 468
              ::.:....:::|  :|               |..|.|.........:.:.....|....||..
Mouse   301 RYKKNIGKFQEEAN--IYAVKTAVSVAQGGHSRTSSPTPPSSAGSGGSFNLSGSGDMFLGMPGLN 363

  Fly   469 GFHQGYP 475
            |  ..||
Mouse   364 G--DSYP 368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:406806	3/4 (75%)
		Homeobox_KN	383..422	CDD:399131	19/41 (46%)
Pbx2	NP_059491.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52		20/74 (27%)
		PBC	50..243	CDD:309062	23/197 (12%)
		homeodomain	245..305	CDD:238039	26/59 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	327..347		3/19 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	375..430

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842691
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X78
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840