Protein Alignment hth and unc-62

DIOPT Version :10

• Sequence 1: NP_476576.1
• Gene: hth / 41273
• FlyBaseID: FBgn0001235
• Length: 487
• Species: Drosophila melanogaster
• Sequence 2: NP_001024169.1
• Gene: unc-62 / 178845
• WormBaseID: WBGene00006796
• Length: 564
• Species: Caenorhabditis elegans
• Alignment Length: 540
• Identity: 204/540 - (37%)
• Similarity: 271/540 - (50%)
• Gaps: 133/540 - (24%)

  Fly    12 GYGMDSGAAAAAMYDPHAGHRPPGLQGLPSHHSPHMTHAAAAAATVGMHGYHSGAGGHGTPSHVS 76
            |||...|:|:|   ||                      |:..|.....:..::..||..|.   :
 Worm    46 GYGPPPGSASA---DP----------------------ASYIADPAAFYNLYTNMGGAPTS---T 82

  Fly    77 PVGNHLMGAIPEVHKRDKDAIYEHPLFPLLALIFEKCELATCTPRE---PGVQGGDVCSSESFNE 138
            |:.:|.||   |..||||::||.|||:|||.|:||||||||.|||:   .|....|||||.||.:
 Worm    83 PMMHHEMG---EAMKRDKESIYAHPLYPLLVLLFEKCELATSTPRDTSRDGSTSSDVCSSASFKD 144

  Fly   139 DIAMFSK--QIRSQKPYYTADPEVDSLMVQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMP 201
            |:..|.:  |..:.|.||..:|::|.:|:|:||:|||||||||||||||||||:||:.|||||||
 Worm   145 DLNEFVRHTQENADKQYYVPNPQLDQIMLQSIQMLRFHLLELEKVHELCDNFCNRYVVCLKGKMP 209

  Fly   202 IDLVIDERDTTKPPEL--GSANGEGRSNADSTSHTDGASTPDVRPP------------------- 245
            :|:|.|||.::..|.:  ||....|.|::.|.:   |.:||...||
 Worm   210 LDIVGDERASSSQPPMSPGSMGHLGHSSSPSMA---GGATPMHYPPPYEPQSVPLPENAGVMGGH 271

  Fly   246 ---SSSLSY------GGAMNDDARSPGAGSTP----GPLSQQPPALDTSDPDGKFLSSLNPSELT 297
               .||::|      ..|.:..:.|..||..|    |.|.....|..|..|    ::..:||..:
 Worm   272 PMEGSSMAYSMAGMAAAAASSSSSSNQAGDHPLANGGTLHSTAGASQTLLP----IAVSSPSTCS 332

  Fly   298 YDGRWCRREWSSP---------ADARNADASRRLYSSVFLGSPDNFGTSASGDASNASIGSGEGT 353
            ..|   .|:.|:|         |:..:.|:...        :.|.|....|.|....|:.|
 Worm   333 SGG---LRQDSTPLSGETPMGHANGNSMDSISE--------AGDEFSVCGSNDDGRDSVLS---- 382

  Fly   354 GEEDDDASGKKNQKKR--GIFPKVATNILRAWLFQHLTHPYPSEDQKKQLAQDTGLTILQVNNWF 416
                |.|:|.:|.|::  .:|.|.|....|||||.:||||||||:||||||::||||||||||||
 Worm   383 ----DSANGSQNGKRKVPKVFSKEAITKFRAWLFHNLTHPYPSEEQKKQLAKETGLTILQVNNWF 443

  Fly   417 INARRRIVQPMIDQSNRAVYTPHPGPSGYGHDAMGYMMDSQAHMMHRPPG---DPGFHQGYPHYP 478
            ||||||||||||||:|||      |.||    .|....:.:.:...:.||   |.|...|..:.|
 Worm   444 INARRRIVQPMIDQNNRA------GRSG----QMNVCKNRRRNRSEQSPGPSPDSGSDSGANYSP 498

  Fly   479 -------------PAEYYGQ 485
                         |||:|.|
 Worm   499 DPSSLAASTAMPYPAEFYMQ 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:465140	52/85 (61%)
		Homeobox_KN	384..422	CDD:428673	32/37 (86%)
unc-62	NP_001024169.1	Meis_PKNOX_N	133..219	CDD:465140	52/85 (61%)
		Homeobox_KN	411..449	CDD:428673	32/37 (86%)