Protein Alignment hth and Meis3

DIOPT Version :9

• Sequence 1: NP_476576.1
• Gene: hth / 41273
• FlyBaseID: FBgn0001235
• Length: 487
• Species: Drosophila melanogaster
• Sequence 2: XP_036008636.1
• Gene: Meis3 / 17537
• MGIID: 108519
• Length: 400
• Species: Mus musculus
• Alignment Length: 521
• Identity: 213/521 - (40%)
• Similarity: 259/521 - (49%)
• Gaps: 173/521 - (33%)

  Fly     5 RYDDGLHGYGMDSGAAAAAMYD-----------PHAGHRPPGLQ--GLPSHHSPHMTHAAAAAAT 56
            |||:..|..|:.....|.|.:.           |:..||||.||  ||.|
Mouse     4 RYDELRHYPGITEHTTALASFSEAAPSVPRAPGPYTPHRPPQLQAPGLDS--------------- 53

  Fly    57 VGMHGYHSGAGGHGTPSHVSPVGNHLMGAIPEVHKRDKDAIYEHPLFPLLALIFEKCELATCTPR 121
                                           :..||:||.||.|||||||||:|||||||||:||
Mouse    54 -------------------------------DSLKREKDDIYGHPLFPLLALVFEKCELATCSPR 87

  Fly   122 E---PGV---QGGDVCSSESFNEDIAMFSKQIRSQKPYYTADPEVDSL----------------- 163
            :   .|:   .|||||||:|||||||.|:|||||::|.::::||:|:|
Mouse    88 DGASAGLGSPPGGDVCSSDSFNEDIAAFAKQIRSERPLFSSNPELDNLNSRWSETESQLCHSSFM 152

  Fly   164 -----MVQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDERDTTKPPELGSANGE 223
                 |||||||||||||||||||:||||||||||:||||||||||||::||       ||...:
Mouse   153 NQGAKMVQAIQVLRFHLLELEKVHDLCDNFCHRYITCLKGKMPIDLVIEDRD-------GSCRED 210

  Fly   224 GRSNADSTSHTDGASTPDVRPPSSSLSYGGAMNDDARSPGAGSTPGPLSQQPPALDTSDPDGKFL 288
            ....|.|.......:|..:|.           ::|:.|...| ||||
Mouse   211 LEDYAASCPSLPDQNTTWIRD-----------HEDSGSVHLG-TPGP------------------ 245

  Fly   289 SSLNPSELTYDGRWCRREWSSPADARNADASRRLYSSVFLGSPDNFGTSASGDASNASIGSGEGT 353
                                               ||..|.|.....:|..||..:.|:.|....
Mouse   246 -----------------------------------SSGGLASQSGDNSSDQGDGLDTSVASPSSA 275

  Fly   354 GEEDDDASGKKNQKKRGIFPKVATNILRAWLFQHLTHPYPSEDQKKQLAQDTGLTILQVNNWFIN 418
            ||::|....::..|||||||||||||:||||||||:||||||:||||||||||||||||||||||
Mouse   276 GEDEDLDLERRRNKKRGIFPKVATNIMRAWLFQHLSHPYPSEEQKKQLAQDTGLTILQVNNWFIN 340

  Fly   419 ARRRIVQPMIDQSNR----AVYTPHPGPSGYGHDAMGYMMDSQAHMMHRPPGDPGFH---QGYPH 476
            |||||||||||||||    |.:.|...|       |....::|..:..|.||..|.:   :|..|
Mouse   341 ARRRIVQPMIDQSNRTGQGASFNPEGQP-------MAGFTETQPQVTVRTPGSMGMNLNLEGEWH 398

  Fly   477 Y 477
            |
Mouse   399 Y 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:406806	67/105 (64%)
		Homeobox_KN	383..422	CDD:399131	36/38 (95%)
Meis3	XP_036008636.1	Meis_PKNOX_N	99..205	CDD:406806	68/112 (61%)
		Homeobox_KN	305..344	CDD:399131	36/38 (95%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842695
Domainoid	1	1.000	157	1.000	Domainoid score	I4146
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	396	1.000	Inparanoid score	I1947
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1126341at2759
OrthoFinder	1	1.000	-	-		FOG0000410
OrthoInspector	1	1.000	-	-		otm43199
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11850
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X78
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.900