Protein Alignment hth and Meis2

DIOPT Version :10

• Sequence 1: NP_476576.1
• Gene: hth / 41273
• FlyBaseID: FBgn0001235
• Length: 487
• Species: Drosophila melanogaster
• Sequence 2: XP_011237639.1
• Gene: Meis2 / 17536
• MGIID: 108564
• Length: 559
• Species: Mus musculus
• Alignment Length: 517
• Identity: 253/517 - (48%)
• Similarity: 300/517 - (58%)
• Gaps: 88/517 - (17%)

  Fly     6 YDDGLHGYGMDSGAAAAAMY-DPHAGHRPPGLQGLPSHHSPHMTHAAAAAATVGMHGYHSGAGGH 69
            ||:..|..|||.....|:|| |||| .||     :|..|  |:.|.....||     .|.||  |
Mouse    24 YDELPHYGGMDGVGVPASMYGDPHA-PRP-----IPPVH--HLNHGPPLHAT-----QHYGA--H 73

  Fly    70 GTPSHVSPVGNHLMG-AIPEVHKRDKDAIYEHPLFPLLALIFEKCELATCTPREPGVQGGDVCSS 133
            ....:|.|..   || |:.:..||||||||.|||||||||:||||||||||||||||.|||||||
Mouse    74 APHPNVMPAS---MGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSS 135

  Fly   134 ESFNEDIAMFSKQIRSQKPYYTADPEVDSLMVQAIQVLRFHLLELEKVHELCDNFCHRYISCLKG 198
            :|||||||:|:||:|::||.::::||:|:||:|||||||||||||||||||||||||||||||||
Mouse   136 DSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKG 200

  Fly   199 KMPIDLVIDERDTTKPPELGSANGEGRSNADST-----SHTDGASTPDVRPPS-SSLSYGGAMND 257
            ||||||||||||.:...:....:|...:.||..     .|.|..||.....|. ||..:.....|
Mouse   201 KMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGHASQSGD 265

  Fly   258 DARSPGAGSTPG-------PLSQQPPALDTSDPDGKFLSSLNPSELTYDGRWCRREWSSPADARN 315
            ::...||..|..       |::.:...:...       .|....|.:.:|:      .||....|
Mouse   266 NSSEQGASETEADHLLLWKPMTDRTGCVSVQ-------MSREDREESREGK------HSPQPLEN 317

  Fly   316 ADASRRLYSSVFLGSPDNFGTS-ASGDASNASIGSGEGTGEEDDDASGKKNQKKRGIFPKVATNI 379
            .         :....|...|.| |.||..:.|:.| .|||::||....||.||||||||||||||
Mouse   318 I---------IIPCQPPFRGESEAGGDGLDNSVAS-PGTGDDDDPDKDKKRQKKRGIFPKVATNI 372

  Fly   380 LRAWLFQHLTHPYPSEDQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNR----------- 433
            :|||||||||||||||:|||||||||||||||||||||||||||||||||||||
Mouse   373 MRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQ 437

  Fly   434 -AVYTPHPGPSGYGHDAMGYMMDSQAHMMHRP------PGD-------PGFHQGYPHYPPAE 481
             |.|:|...|.|      .:::|.|.||..||      |||       .|.....|.|.|.:
Mouse   438 GAAYSPEGQPMG------SFVLDGQQHMGIRPAGLQSMPGDYVSQGGPMGMGMAQPSYTPPQ 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:465140	69/83 (83%)
		Homeobox_KN	384..422	CDD:428673	36/37 (97%)
Meis2	XP_011237639.1	Meis_PKNOX_N	129..213	CDD:465140	69/83 (83%)
		Homeobox_KN	377..415	CDD:428673	36/37 (97%)