DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hth and Meis2

DIOPT Version :9

Sequence 1:	NP_476576.1	Gene:	hth / 41273	FlyBaseID:	FBgn0001235	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	XP_011237639.1	Gene:	Meis2 / 17536	MGIID:	108564	Length:	559	Species:	Mus musculus

Alignment Length:	517	Identity:	253/517 - (48%)
Similarity:	300/517 - (58%)	Gaps:	88/517 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 YDDGLHGYGMDSGAAAAAMY-DPHAGHRPPGLQGLPSHHSPHMTHAAAAAATVGMHGYHSGAGGH 69
            ||:..|..|||.....|:|| |||| .||     :|..|  |:.|.....||     .|.||  |
Mouse    24 YDELPHYGGMDGVGVPASMYGDPHA-PRP-----IPPVH--HLNHGPPLHAT-----QHYGA--H 73

  Fly    70 GTPSHVSPVGNHLMG-AIPEVHKRDKDAIYEHPLFPLLALIFEKCELATCTPREPGVQGGDVCSS 133
            ....:|.|..   || |:.:..||||||||.|||||||||:||||||||||||||||.|||||||
Mouse    74 APHPNVMPAS---MGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSS 135

  Fly   134 ESFNEDIAMFSKQIRSQKPYYTADPEVDSLMVQAIQVLRFHLLELEKVHELCDNFCHRYISCLKG 198
            :|||||||:|:||:|::||.::::||:|:||:|||||||||||||||||||||||||||||||||
Mouse   136 DSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKG 200

  Fly   199 KMPIDLVIDERDTTKPPELGSANGEGRSNADST-----SHTDGASTPDVRPPS-SSLSYGGAMND 257
            ||||||||||||.:...:....:|...:.||..     .|.|..||.....|. ||..:.....|
Mouse   201 KMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGHASQSGD 265

  Fly   258 DARSPGAGSTPG-------PLSQQPPALDTSDPDGKFLSSLNPSELTYDGRWCRREWSSPADARN 315
            ::...||..|..       |::.:...:...       .|....|.:.:|:      .||....|
Mouse   266 NSSEQGASETEADHLLLWKPMTDRTGCVSVQ-------MSREDREESREGK------HSPQPLEN 317

  Fly   316 ADASRRLYSSVFLGSPDNFGTS-ASGDASNASIGSGEGTGEEDDDASGKKNQKKRGIFPKVATNI 379
            .         :....|...|.| |.||..:.|:.| .|||::||....||.||||||||||||||
Mouse   318 I---------IIPCQPPFRGESEAGGDGLDNSVAS-PGTGDDDDPDKDKKRQKKRGIFPKVATNI 372

  Fly   380 LRAWLFQHLTHPYPSEDQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNR----------- 433
            :|||||||||||||||:|||||||||||||||||||||||||||||||||||||
Mouse   373 MRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQ 437

  Fly   434 -AVYTPHPGPSGYGHDAMGYMMDSQAHMMHRP------PGD-------PGFHQGYPHYPPAE 481
             |.|:|...|.|      .:::|.|.||..||      |||       .|.....|.|.|.:
Mouse   438 GAAYSPEGQPMG------SFVLDGQQHMGIRPAGLQSMPGDYVSQGGPMGMGMAQPSYTPPQ 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:406806	69/83 (83%)
hth	NP_476576.1	Homeobox_KN	383..422	CDD:399131	37/38 (97%)
Meis2	XP_011237639.1	Meis_PKNOX_N	129..213	CDD:374576	69/83 (83%)
Meis2	XP_011237639.1	Homeobox_KN	376..415	CDD:368670	37/38 (97%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842699
Domainoid	1	1.000	157	1.000	Domainoid score	I4146
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	396	1.000	Inparanoid score	I1947
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000410
OrthoInspector	1	1.000	-	-		otm43199
orthoMCL	1	0.900	-	-		OOG6_105229
Panther	1	1.100	-	-	LDO	PTHR11850
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2315
SonicParanoid	1	1.000	-	-		X78
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.780