DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hth and meis1a

DIOPT Version :9

Sequence 1:	NP_476576.1	Gene:	hth / 41273	FlyBaseID:	FBgn0001235	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_571972.2	Gene:	meis1a / 170455	ZFINID:	ZDB-GENE-020122-3	Length:	380	Species:	Danio rerio

Alignment Length:	495	Identity:	242/495 - (48%)
Similarity:	282/495 - (56%)	Gaps:	134/495 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAQPRYDDGLHGYGMDSGAAAAAMY-DPHAGHRPPGLQGLPSHHSPHMTHAAAAAATVGMHGYHS 64
            ||| ||:|.:| ||||:....:.|| ||||..   .:|.:...|.|            .:|.|..
Zfish     1 MAQ-RYEDLVH-YGMDAVGIPSPMYGDPHAAR---AMQAVHVSHGP------------PLHPYPH 48

  Fly    65 GAGGHGTPSHVSPVGNHLMGAIPEVHKRDKDAIYEHPLFPLLALIFEKCELATCTPREPGVQGGD 129
            .|...|.|   .||.:.|        ||||||||.|||||||||:|||||||||||||.||. ||
Zfish    49 PATAPGVP---PPVNDAL--------KRDKDAIYGHPLFPLLALVFEKCELATCTPRESGVT-GD 101

  Fly   130 VCSSESFNEDIAMFSKQIRSQKPYYTADPEVDSLMVQAIQVLRFHLLELEKVHELCDNFCHRYIS 194
            |||||||:|||.:||||||::||:::::|::|:||:|||||||||||||||||||||||||||||
Zfish   102 VCSSESFDEDITVFSKQIRAEKPFFSSNPDLDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYIS 166

  Fly   195 CLKGKMPIDLVIDERDTTKPPELGSANGEGRSNADSTSHTDGASTPDVRPPSSSLSYGGA----- 254
            |||||||||||:|::             ||.|.:|....|        |.|      ||:
Zfish   167 CLKGKMPIDLVVDDK-------------EGGSRSDGEEFT--------RTP------GGSEQVFW 204

  Fly   255 MNDDARSPGAGSTPGPLSQQPPALDTSDPDGKFLSSLNPSELTYDGRWCRREWSSPADARNADAS 319
            ..||..|..:..||..                                |.|..||    .|.|.|
Zfish   205 REDDTASVHSTDTPAA--------------------------------CGRRSSS----HNGDNS 233

  Fly   320 RRLYSSVFLGSPDNFGTSASGDASNASIGSGEGTGEEDDDASGKKNQKKRGIFPKVATNILRAWL 384
                             |..||..:.|:.| ..||||:|....:||.|||||||||||||:||||
Zfish   234 -----------------SEHGDFLDQSVAS-PSTGEEEDPDKERKNNKKRGIFPKVATNIMRAWL 280

  Fly   385 FQHLTHPYPSEDQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAV-----YTPHPGPSG 444
            |||||||||||:||:||:|||||||||||||||||||||||||||||||||     |||...|.|
Zfish   281 FQHLTHPYPSEEQKRQLSQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVGHSGPYTPDAQPMG 345

  Fly   445 YGHDAMGYMMDSQAHMMHRPP----GDPGFHQGYP---HY 477
                  |::||.|:||..|||    |..|.:.|..   ||
Zfish   346 ------GFVMDGQSHMGIRPPAALGGLGGVNMGLESQWHY 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:406806	65/83 (78%)
hth	NP_476576.1	Homeobox_KN	383..422	CDD:399131	35/38 (92%)
meis1a	NP_571972.2	Meis_PKNOX_N	99..182	CDD:293102	65/96 (68%)
meis1a	NP_571972.2	Homeobox_KN	279..318	CDD:283551	35/38 (92%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587114
Domainoid	1	1.000	157	1.000	Domainoid score	I4115
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	392	1.000	Inparanoid score	I1935
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1126341at2759
OrthoFinder	1	1.000	-	-		FOG0000410
OrthoInspector	1	1.000	-	-		otm24280
orthoMCL	1	0.900	-	-		OOG6_105229
Panther	1	1.100	-	-	O	PTHR11850
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2315
SonicParanoid	1	1.000	-	-		X78
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790