Protein Alignment hth and meis2a

DIOPT Version :9

• Sequence 1: NP_476576.1
• Gene: hth / 41273
• FlyBaseID: FBgn0001235
• Length: 487
• Species: Drosophila melanogaster
• Sequence 2: XP_009291615.1
• Gene: meis2a / 170454
• ZFINID: ZDB-GENE-020122-2
• Length: 409
• Species: Danio rerio
• Alignment Length: 498
• Identity: 248/498 - (49%)
• Similarity: 290/498 - (58%)
• Gaps: 111/498 - (22%)

  Fly     1 MAQPRYDDGLHGYGMDSGAAAAAMY-DPHAGHRPPGLQGLPSHHSPHMTHAAAAAATVGMHGYHS 64
            ||| |||:..|..|||    ...|| |||| .||     ||..|  |:.|.....|:     .|.
Zfish     1 MAQ-RYDELAHYGGMD----GVGMYGDPHA-PRP-----LPQVH--HLNHGPPLHAS-----QHY 47

  Fly    65 GAGGHGTPSHVSPVGNHLMG-AIPEVHKRDKDAIYEHPLFPLLALIFEKCELATCTPREPGVQGG 128
            |.  |....:|.|..   || |:.:|.|||||.||.|||||||||:||||||||||||||||.||
Zfish    48 GT--HAPHPNVMPTS---MGSAVNDVLKRDKDQIYGHPLFPLLALVFEKCELATCTPREPGVAGG 107

  Fly   129 DVCSSESFNEDIAMFSKQIRSQKPYYTADPEVDSLMVQAIQVLRFHLLELEKVHELCDNFCHRYI 193
            |||||:|||||||:|:||:|::||.::::||:|:||:||||||||||||||||||||||||||||
Zfish   108 DVCSSDSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYI 172

  Fly   194 SCLKGKMPIDLVIDERDTTKPPELGSANGEGRSNADSTSHTDGASTPD-VRPPSSSLSYGGAMND 257
            |||||||||||||||||.:...:....:|...:.||...  :|....| ::.|:|...:     |
Zfish   173 SCLKGKMPIDLVIDERDGSSKSDHEELSGSSTNLADHMG--NGWIRSDRLQNPASWRDH-----D 230

  Fly   258 DARSPGAGSTPGPLSQQPPALDTSDPDGKFLSSLNPSELTYDGRWCRREWSSPADARNADASRRL 322
            ||.|..:..||||
Zfish   231 DATSTHSAGTPGP---------------------------------------------------- 243

  Fly   323 YSSVFLGSPDNFGTSASGDASNASIGSGEGTGEEDDDASGKKNQKKRGIFPKVATNILRAWLFQH 387
             ||..|.|.....:|..||..:.|:.| .|||::||....||.||||||||||||||:|||||||
Zfish   244 -SSGGLASQSGDNSSEQGDGLDNSVAS-PGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQH 306

  Fly   388 LTHPYPSEDQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNR------------AVYTPHP 440
            ||||||||:|||||||||||||||||||||||||||||||||||||            |.|:|..
Zfish   307 LTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYSPEG 371

  Fly   441 GPSGYGHDAMGYMMDSQAHMMHRPPG---DPGFHQGYP---HY 477
            .|.|      .:::|.|.||..||.|   ..|.:.|..   ||
Zfish   372 QPMG------SFVLDGQQHMGIRPAGPMSGMGMNMGMDGQWHY 408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:406806	69/83 (83%)
		Homeobox_KN	383..422	CDD:399131	37/38 (97%)
meis2a	XP_009291615.1	Meis_PKNOX_N	106..189	CDD:293102	68/82 (83%)
		Homeobox_KN	302..341	CDD:283551	37/38 (97%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587120
Domainoid	1	1.000	157	1.000	Domainoid score	I4115
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	392	1.000	Inparanoid score	I1935
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1126341at2759
OrthoFinder	1	1.000	-	-		FOG0000410
OrthoInspector	1	1.000	-	-		otm24280
orthoMCL	1	0.900	-	-		OOG6_105229
Panther	1	1.100	-	-	LDO	PTHR11850
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X78
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.900