Protein Alignment hth and meis2a

DIOPT Version :10

• Sequence 1: NP_476576.1
• Gene: hth / 41273
• FlyBaseID: FBgn0001235
• Length: 487
• Species: Drosophila melanogaster
• Sequence 2: XP_009291615.1
• Gene: meis2a / 170454
• ZFINID: ZDB-GENE-020122-2
• Length: 409
• Species: Danio rerio
• Alignment Length: 498
• Identity: 248/498 - (49%)
• Similarity: 290/498 - (58%)
• Gaps: 111/498 - (22%)

  Fly     1 MAQPRYDDGLHGYGMDSGAAAAAMY-DPHAGHRPPGLQGLPSHHSPHMTHAAAAAATVGMHGYHS 64
            ||| |||:..|..|||    ...|| |||| .||     ||..|  |:.|.....|:     .|.
Zfish     1 MAQ-RYDELAHYGGMD----GVGMYGDPHA-PRP-----LPQVH--HLNHGPPLHAS-----QHY 47

  Fly    65 GAGGHGTPSHVSPVGNHLMG-AIPEVHKRDKDAIYEHPLFPLLALIFEKCELATCTPREPGVQGG 128
            |.  |....:|.|..   || |:.:|.|||||.||.|||||||||:||||||||||||||||.||
Zfish    48 GT--HAPHPNVMPTS---MGSAVNDVLKRDKDQIYGHPLFPLLALVFEKCELATCTPREPGVAGG 107

  Fly   129 DVCSSESFNEDIAMFSKQIRSQKPYYTADPEVDSLMVQAIQVLRFHLLELEKVHELCDNFCHRYI 193
            |||||:|||||||:|:||:|::||.::::||:|:||:||||||||||||||||||||||||||||
Zfish   108 DVCSSDSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYI 172

  Fly   194 SCLKGKMPIDLVIDERDTTKPPELGSANGEGRSNADSTSHTDGASTPD-VRPPSSSLSYGGAMND 257
            |||||||||||||||||.:...:....:|...:.||...  :|....| ::.|:|...:     |
Zfish   173 SCLKGKMPIDLVIDERDGSSKSDHEELSGSSTNLADHMG--NGWIRSDRLQNPASWRDH-----D 230

  Fly   258 DARSPGAGSTPGPLSQQPPALDTSDPDGKFLSSLNPSELTYDGRWCRREWSSPADARNADASRRL 322
            ||.|..:..||||
Zfish   231 DATSTHSAGTPGP---------------------------------------------------- 243

  Fly   323 YSSVFLGSPDNFGTSASGDASNASIGSGEGTGEEDDDASGKKNQKKRGIFPKVATNILRAWLFQH 387
             ||..|.|.....:|..||..:.|:.| .|||::||....||.||||||||||||||:|||||||
Zfish   244 -SSGGLASQSGDNSSEQGDGLDNSVAS-PGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQH 306

  Fly   388 LTHPYPSEDQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNR------------AVYTPHP 440
            ||||||||:|||||||||||||||||||||||||||||||||||||            |.|:|..
Zfish   307 LTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYSPEG 371

  Fly   441 GPSGYGHDAMGYMMDSQAHMMHRPPG---DPGFHQGYP---HY 477
            .|.|      .:::|.|.||..||.|   ..|.:.|..   ||
Zfish   372 QPMG------SFVLDGQQHMGIRPAGPMSGMGMNMGMDGQWHY 408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:465140	69/83 (83%)
		Homeobox_KN	384..422	CDD:428673	36/37 (97%)
meis2a	XP_009291615.1	Meis_PKNOX_N	106..190	CDD:465140	69/83 (83%)
		Homeobox_KN	303..341	CDD:428673	36/37 (97%)