DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hth and meis1b

DIOPT Version :9

Sequence 1:	NP_476576.1	Gene:	hth / 41273	FlyBaseID:	FBgn0001235	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_571968.1	Gene:	meis1b / 170446	ZFINID:	ZDB-GENE-020122-1	Length:	388	Species:	Danio rerio

Alignment Length:	495	Identity:	249/495 - (50%)
Similarity:	284/495 - (57%)	Gaps:	126/495 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAQPRYDDGLHGYGMDSGAAAAAMY-DPHAG------HRPPGLQGLPSHHSPHMTHAAAAAATVG 58
            ||| ||:|..| ||||.....:.|| ||||.      |...|.| |.||..||..|..|...::|
Zfish     1 MAQ-RYEDIPH-YGMDGVGIPSTMYGDPHAARSMQAVHLNHGPQ-LHSHQYPHTAHTNAMPPSMG 62

  Fly    59 MHGYHSGAGGHGTPSHVSPVGNHLMGAIPEVHKRDKDAIYEHPLFPLLALIFEKCELATCTPREP 123
                                     .::.:..|||||:||.||||||||||||||||||||||||
Zfish    63 -------------------------SSVNDALKRDKDSIYGHPLFPLLALIFEKCELATCTPREP 102

  Fly   124 GVQGGDVCSSESFNEDIAMFSKQIRSQKPYYTADPEVDSLMVQAIQVLRFHLLELEKVHELCDNF 188
            ||.|||||||||||||||:|:||||::||.::::||:|:||:|||||||||||||||||||||||
Zfish   103 GVAGGDVCSSESFNEDIAVFAKQIRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNF 167

  Fly   189 CHRYISCLKGKMPIDLVIDERDTTKPPELGSANGEGRSNADSTSHTDGASTPDVRPPSSSLSYGG 253
            |||||||||||||||||||:|             ||.|.:||...|..:.      |....|: .
Zfish   168 CHRYISCLKGKMPIDLVIDDR-------------EGGSKSDSEEITRSSG------PLDQTSW-N 212

  Fly   254 AMNDDARSPGAGSTPGPLSQQPPALDTSDPDGKFLSSLNPSELTYDGRWCRREWSSPADARNADA 318
            ..:||..|..:|.||||.|            |...|.
Zfish   213 RDHDDTASTRSGGTPGPSS------------GGHTSH---------------------------- 237

  Fly   319 SRRLYSSVFLGSPDNFGTSASGDASNASIGSGEGTGEEDDDASGKKNQKKRGIFPKVATNILRAW 383
                       |.||  :|..||..:.|:.| ..||::||....||..|||||||||||||:|||
Zfish   238 -----------SGDN--SSEQGDGLDNSVAS-PSTGDDDDPDKEKKRNKKRGIFPKVATNIMRAW 288

  Fly   384 LFQHLTHPYPSEDQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAV-----YTPHPGPS 443
            ||||||||||||:|||||||||||||||||||||||||||||||||||||||     |.|...|.
Zfish   289 LFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGAPYNPDGQPM 353

  Fly   444 GYGHDAMGYMMDSQAHMMHRPPG---DPGFHQGYP---HY 477
            |      |::||.|.||..||||   ..|.:.|..   ||
Zfish   354 G------GFVMDGQQHMGIRPPGPMSGMGMNMGMEGQWHY 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:406806	70/83 (84%)
hth	NP_476576.1	Homeobox_KN	383..422	CDD:399131	37/38 (97%)
meis1b	NP_571968.1	Meis_PKNOX_N	106..190	CDD:406806	70/96 (73%)
meis1b	NP_571968.1	Homeobox_KN	288..327	CDD:399131	37/38 (97%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587113
Domainoid	1	1.000	157	1.000	Domainoid score	I4115
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H86803
Inparanoid	1	1.050	392	1.000	Inparanoid score	I1935
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1126341at2759
OrthoFinder	1	1.000	-	-		FOG0000410
OrthoInspector	1	1.000	-	-		otm24280
orthoMCL	1	0.900	-	-		OOG6_105229
Panther	1	1.100	-	-	O	PTHR11850
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2315
SonicParanoid	1	1.000	-	-		X78
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.790