DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hth and Irx3

DIOPT Version :9

Sequence 1:	NP_476576.1	Gene:	hth / 41273	FlyBaseID:	FBgn0001235	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_001240751.1	Gene:	Irx3 / 16373	MGIID:	1197522	Length:	522	Species:	Mus musculus

Alignment Length:	237	Identity:	54/237 - (22%)
Similarity:	85/237 - (35%)	Gaps:	92/237 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   240 PDVRPPSSSLSYGGAMNDDARSPGAGSTPGPLSQQPPALDTSDPDGKFLSSLNPSELTYDGRWCR 304
            |..||.::....||:.......||||:                           |||...|
Mouse    16 PPERPGAAGGGGGGSSAGGRSGPGAGA---------------------------SELAASG---- 49

  Fly   305 REWSSPADARNADASRRLYSSVFLGSPDNFGTSASGDASNASIGSGE--------------GTGE 355
                         :...:.|||: |:|    .:|:..|:.|:.|.|.              |...
Mouse    50 -------------SLSNVLSSVY-GAP----YAAAAAAAAAAQGYGAFLPYATELPIFPQLGAQY 96

  Fly   356 EDDDASGKKNQKKRGIFP------------------------KVATNILRAWLFQHLTHPYPSED 396
            |..|:.|.::......||                        :.:|:.|:|||.:|..:|||::.
Mouse    97 ELKDSPGVQHPATAAAFPHPHPAFYPYGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKG 161

  Fly   397 QKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVYTP 438
            :|..||..|.:|:.||:.||.|||||     :.:.|:..:.|
Mouse   162 EKIMLAIITKMTLTQVSTWFANARRR-----LKKENKMTWAP 198

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:406806
hth	NP_476576.1	Homeobox_KN	383..422	CDD:399131	18/38 (47%)
Irx3	NP_001240751.1	Homeobox_KN	148..187	CDD:283551	18/38 (47%)
Irx3	NP_001240751.1	IRO	345..362	CDD:214716
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900