DRSC/TRiP Functional Genomics Resources

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Protein Alignment hth and Irx2

DIOPT Version :9

Sequence 1:NP_476576.1 Gene:hth / 41273 FlyBaseID:FBgn0001235 Length:487 Species:Drosophila melanogaster
Sequence 2:NP_034704.1 Gene:Irx2 / 16372 MGIID:1197526 Length:474 Species:Mus musculus


Alignment Length:181 Identity:56/181 - (30%)
Similarity:84/181 - (46%) Gaps:26/181 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   263 GAGSTPGPLSQQPPALDTSDPDGKFLSSLNPSELTYDGRWCRREWSSP----ADARNADASRRLY 323
            ||.:...|.|::   |..|.....|  |..|....:..: ....:.||    |||..|.|:.  :
Mouse    24 GASALAAPRSEE---LARSASGSAF--SPYPGSAAFTAQ-AATGFGSPLQYSADAAAAAAAG--F 80

  Fly   324 SSVFLGSP-DNFGTSASGDASNASIGSGEGTGEEDDDASGKKNQKKRGIFPKVATNILRAWLFQH 387
            .| ::||| |...|..:|..|....||.....:.:|.|. :||..:.      ||..|:|||.:|
Mouse    81 PS-YVGSPYDTHTTGMTGAISYHPYGSAAYPYQLNDPAY-RKNATRD------ATATLKAWLNEH 137

  Fly   388 LTHPYPSEDQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVYTP 438
            ..:|||::.:|..||..|.:|:.||:.||.|||||     :.:.|:..:.|
Mouse   138 RKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRR-----LKKENKMTWAP 183

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hthNP_476576.1 Meis_PKNOX_N 127..211 CDD:406806
Homeobox_KN 383..422 CDD:399131 18/38 (47%)
Irx2NP_034704.1 COG5576 <115..217 CDD:227863 30/81 (37%)
Homeobox_KN 133..172 CDD:368670 18/38 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 177..220 2/7 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 262..373
IRO 325..342 CDD:214716
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 420..461
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0773
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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