DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hth and Irx1

DIOPT Version :9

Sequence 1:	NP_476576.1	Gene:	hth / 41273	FlyBaseID:	FBgn0001235	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_034703.2	Gene:	Irx1 / 16371	MGIID:	1197515	Length:	480	Species:	Mus musculus

Alignment Length:	196	Identity:	50/196 - (25%)
Similarity:	79/196 - (40%)	Gaps:	55/196 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   259 ARSPGA--GSTPGPLSQQPPALDTSDPDGKFLSSLNPSELTYDGRWCRREWSSPADARNADASRR 321
            |..|||  |..||.|:....|...:.                .||....|..:.|.|....:...
Mouse    14 AAGPGAYGGERPGVLAAAAAAAAAAS----------------SGRPGTAELGAGAGAAAVTSVLG 62

  Fly   322 LYSSV--FLGSPDNFGTSASGDASNASIGSGEGTGEEDDDASG---------------------- 362
            :|::.  :.|:| |: ::....|::.|:.|..|:..|..|..|
Mouse    63 MYAAAGPYAGAP-NY-SAFLPYAADLSLFSQMGSQYELKDNPGVHPATFAAHTTPAYYPYGQFQY 125

  Fly   363 -----KKNQKKRGIFPKVATNILRAWLFQHLTHPYPSEDQKKQLAQDTGLTILQVNNWFINARRR 422
                 .||..:.      :|:.|:|||.:|..:|||::.:|..||..|.:|:.||:.||.|||||
Mouse   126 GDPGRPKNATRE------STSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRR 184

  Fly   423 I 423
            :
Mouse   185 L 185

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:406806
hth	NP_476576.1	Homeobox_KN	383..422	CDD:399131	18/38 (47%)
Irx1	NP_034703.2	Homeobox_KN	145..184	CDD:283551	18/38 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	190..285
		SDA1	<194..>252	CDD:283052
		IRO	309..326	CDD:214716
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..354
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	401..480
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810