DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hth and IRX2

DIOPT Version :9

Sequence 1:	NP_476576.1	Gene:	hth / 41273	FlyBaseID:	FBgn0001235	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_001127694.1	Gene:	IRX2 / 153572	HGNCID:	14359	Length:	471	Species:	Homo sapiens

Alignment Length:	181	Identity:	55/181 - (30%)
Similarity:	81/181 - (44%)	Gaps:	27/181 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   263 GAGSTPGPLSQQPPALDTSDPDGKFLSSLNPSELTYDGRWCRREWSSP----ADARNADASRRLY 323
            ||.:...|.|::   |..|.....|  |..|....:..: ....:.||    |||..|.|....|
Human    24 GASALAAPRSEE---LARSASGSAF--SPYPGSAAFTAQ-AATGFGSPLQYSADAAAAAAGFPSY 82

  Fly   324 SSVFLGSP-DNFGTSASGDASNASIGSGEGTGEEDDDASGKKNQKKRGIFPKVATNILRAWLFQH 387
                :|:| |...|..:|..|....||.....:.:|.|. :||..:.      ||..|:|||.:|
Human    83 ----MGAPYDAHTTGMTGAISYHPYGSAAYPYQLNDPAY-RKNATRD------ATATLKAWLNEH 136

  Fly   388 LTHPYPSEDQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVYTP 438
            ..:|||::.:|..||..|.:|:.||:.||.|||||     :.:.|:..:.|
Human   137 RKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRR-----LKKENKMTWAP 182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:406806
hth	NP_476576.1	Homeobox_KN	383..422	CDD:399131	18/38 (47%)
IRX2	NP_001127694.1	Homeobox_KN	132..171	CDD:283551	18/38 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..373		2/7 (29%)
		IRO	322..339	CDD:214716
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	424..471
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900