DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hth and meis1

DIOPT Version :9

Sequence 1:	NP_476576.1	Gene:	hth / 41273	FlyBaseID:	FBgn0001235	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	XP_002931792.1	Gene:	meis1 / 100488182	XenbaseID:	XB-GENE-479439	Length:	465	Species:	Xenopus tropicalis

Alignment Length:	500	Identity:	252/500 - (50%)
Similarity:	285/500 - (56%)	Gaps:	122/500 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAQPRYDDGLHGYGMDSGAAAAAMY-DPHA----------GHRPPGLQGLPSHHSPHMTHAAAAA 54
            ||| ||||..|..|||.....:.|| ||||          .|.||    |.||..||..|..|..
Frog     1 MAQ-RYDDLPHYGGMDGVGIPSTMYGDPHAARSMQPVHHLNHGPP----LHSHQYPHTAHTNAMP 60

  Fly    55 ATVGMHGYHSGAGGHGTPSHVSPVGNHLMGAIPEVHKRDKDAIYEHPLFPLLALIFEKCELATCT 119
            .::|                         .::.:..||||||||.||||||||||||||||||||
Frog    61 PSMG-------------------------SSVNDALKRDKDAIYGHPLFPLLALIFEKCELATCT 100

  Fly   120 PREPGVQGGDVCSSESFNEDIAMFSKQIRSQKPYYTADPEVDSLMVQAIQVLRFHLLELEKVHEL 184
            ||||||.|||||||||||||||:|:||||::||.::::||:|:||:|||||||||||||||||||
Frog   101 PREPGVAGGDVCSSESFNEDIAVFAKQIRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHEL 165

  Fly   185 CDNFCHRYISCLKGKMPIDLVIDERDTTKPPELGSANGEGRSNADSTSHTDGASTPDVRPPSSSL 249
            ||||||||||||||||||||||::|             ||.|.:||...|..|...|  .||.|.
Frog   166 CDNFCHRYISCLKGKMPIDLVIEDR-------------EGGSKSDSEDMTRSAPLTD--QPSWSR 215

  Fly   250 SYGGAMNDDARSPGAGSTPGPLSQQPPALDTSDPDGKFLSSLNPSELTYDGRWCRREWSSPADAR 314
            .:     ||..|..:|.||||.|            |...|.
Frog   216 DH-----DDTASTRSGGTPGPSS------------GGHTSH------------------------ 239

  Fly   315 NADASRRLYSSVFLGSPDNFGTSASGDASNASIGSGEGTGEEDDDASGKKNQKKRGIFPKVATNI 379
                           |.||  :|..||..:.|:.| ..||::||....||..|||||||||||||
Frog   240 ---------------SGDN--SSEQGDGLDNSVAS-PSTGDDDDPDKDKKRHKKRGIFPKVATNI 286

  Fly   380 LRAWLFQHLTHPYPSEDQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVY--TPHPGP 442
            :|||||||||||||||:|||||||||||||||||||||||||||||||||||||||.  ||:
Frog   287 MRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPY--- 348

  Fly   443 SGYGHDAMGYMMDSQAHMMHRPPGDPGFHQGY--PHYPPAEYYGQ 485
            :..|....|::||.|.||..|.||..|....|  |..|.....||
Frog   349 NADGQPMGGFVMDGQQHMGIRAPGLQGMPGSYISPSGPMGMSMGQ 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:406806	69/83 (83%)
hth	NP_476576.1	Homeobox_KN	383..422	CDD:399131	37/38 (97%)
meis1	XP_002931792.1	Meis_PKNOX_N	108..192	CDD:374576	69/96 (72%)
meis1	XP_002931792.1	Homeobox_KN	290..329	CDD:368670	37/38 (97%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	155	1.000	Domainoid score	I4177
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H86803
Inparanoid	1	1.050	381	1.000	Inparanoid score	I2010
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1126341at2759
OrthoFinder	1	1.000	-	-		FOG0000410
OrthoInspector	1	1.000	-	-		otm48338
Panther	1	1.100	-	-	O	PTHR11850
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X78
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.070