DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hth and pbx2

DIOPT Version :9

Sequence 1:	NP_476576.1	Gene:	hth / 41273	FlyBaseID:	FBgn0001235	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_001122133.1	Gene:	pbx2 / 100101713	XenbaseID:	XB-GENE-484669	Length:	422	Species:	Xenopus tropicalis

Alignment Length:	412	Identity:	86/412 - (20%)
Similarity:	127/412 - (30%)	Gaps:	183/412 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 GAGGHGTPSHVSPVGNHLMGAIPEVHKRDKDAIYEHPLFPLLALIFEKCELATCTPREPGVQGGD 129
            |.|..|.|.|..|                 ..:..||:                  .||....|
Frog    12 GVGIPGHPIHGGP-----------------QTLTPHPM------------------HEPPADNG- 40

  Fly   130 VCSSESFNEDIAMFSKQIRSQKPYYTADPEVDSLMVQAIQVLRFHLLELEKVHELCDNFCHRY-- 192
                |...:||....:||.:     ..|..:|.  .||            |.|.|   .|||.
Frog    41 ----EPRKQDIGDILQQIMT-----ITDQSLDE--AQA------------KKHAL---NCHRMKP 79

  Fly   193 ----ISC-LKGKMPIDLVIDERDTTKPPEL-------------GSANGEGRSNADSTSHTDGAST 239
                :.| :|.|..:.:...:.:....|:|             |...|.|.:.|.:.:...|..:
Frog    80 ALFSVLCEIKEKTGLSIRNTQEEEPVDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGVS 144

  Fly   240 PDVRPPSSSLSYGGAMNDDARSPGAGSTPGPLSQQPPALDTSDPDGKFLSSLNPSELTYDGRWCR 304
            ||     :|:.:....|             .|||              :..:..:||....:.|.
Frog   145 PD-----NSIEHSDYRN-------------KLSQ--------------IRQIYHAELEKYEQACN 177

  Fly   305 ----------REWS-----SPAD-ARNADASRRLYSSV------------------FLGSPDNFG 335
                      ||.|     ||.: .|......|.:||:                  ||
Frog   178 EFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVMILRSRFL------- 235

  Fly   336 TSASGDASNASIGSGEGTGEEDDDASGKKNQKKRGIFPKVATNILRAWLFQHLTHPYPSEDQKKQ 400
                                   ||     ::||..|.|.||.:|..:.:.||::|||||:.|::
Frog   236 -----------------------DA-----RRKRRNFSKQATEVLNEYFYSHLSNPYPSEEAKEE 272

  Fly   401 LAQDTGLTILQVNNWFINARRR 422
            ||:..|:|:.||:|||.|.|.|
Frog   273 LAKKCGITVSQVSNWFGNKRIR 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:406806	19/90 (21%)
hth	NP_476576.1	Homeobox_KN	383..422	CDD:399131	19/38 (50%)
pbx2	NP_001122133.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43		12/70 (17%)
		PBC	44..236	CDD:367661	45/275 (16%)
		homeodomain	238..298	CDD:238039	27/57 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	319..341
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	353..422
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X78
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910