DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hth and irx1

DIOPT Version :9

Sequence 1:	NP_476576.1	Gene:	hth / 41273	FlyBaseID:	FBgn0001235	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_001188351.1	Gene:	irx1 / 100038208	XenbaseID:	XB-GENE-486817	Length:	467	Species:	Xenopus tropicalis

Alignment Length:	183	Identity:	51/183 - (27%)
Similarity:	79/183 - (43%)	Gaps:	28/183 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 YGGAMNDDARSPGAGSTPGPLSQQPPALDTSDPDGKFLSSLNPSELTYDGRWCRREWSSPADARN 315
            |||      ..||..:.....:....|..:..|.|..|.|.:.:.:|.    ....::||..|.|
Frog    20 YGG------ERPGVLAAAAAAAAAAAAAGSGRPTGADLGSSSTAAVTS----VLGMYASPYSAPN 74

  Fly   316 ADA------SRRLYSSVFLGS----PDNFGTSASGDASNASIGSGEGTGEEDDDASGKKNQKKRG 370
            ..|      ...|:|.  :||    .||.|...:..|::.:.|.......:..|....||..:.
Frog    75 YSAFLPYTTDLTLFSQ--MGSQYELKDNPGVHPATFAAHTTPGYYPYGQFQYGDPGRPKNATRE- 136

  Fly   371 IFPKVATNILRAWLFQHLTHPYPSEDQKKQLAQDTGLTILQVNNWFINARRRI 423
                 :|:.|:|||.:|..:|||::.:|..||..|.:|:.||:.||.|||||:
Frog   137 -----STSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRL 184

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:406806
hth	NP_476576.1	Homeobox_KN	383..422	CDD:399131	18/38 (47%)
irx1	NP_001188351.1	Homeobox_KN	144..183	CDD:283551	18/38 (47%)
irx1	NP_001188351.1	IRO	303..320	CDD:214716
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910