DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hth and irx4

DIOPT Version :9

Sequence 1:	NP_476576.1	Gene:	hth / 41273	FlyBaseID:	FBgn0001235	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_001263621.1	Gene:	irx4 / 100038068	XenbaseID:	XB-GENE-480570	Length:	496	Species:	Xenopus tropicalis

Alignment Length:	242	Identity:	58/242 - (23%)
Similarity:	92/242 - (38%)	Gaps:	83/242 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 ASTPDVRPPSSSL-----SYGGAMNDDARSPGAGSTPGPLSQQPPALDTSDPDGKFLSSLNPSEL 296
            :|||.....::||     |.|.:::|.|.:..|         |.|....
Frog    11 SSTPQFLMTTNSLSTCCESSGRSLSDSAAAASA---------QTPVYCP---------------- 50

  Fly   297 TYDGRWCRREWSSPADAR---NADASRRLYSSVF-----LGSPDNFGTSASGDASNASIGSGEGT 353
            .|:.|..       |.||   |:.|:..:|.|.:     .|:...:|..||...|..:..|.:||
Frog    51 VYESRLL-------ATARHELNSAAALGVYGSPYTSTQGYGNYVTYGADASAFYSLNAFESKDGT 108

  Fly   354 GEED---------------------------DDASGKKNQKKRGIFPKVATNILRAWLFQHLTHP 391
            |...                           |.::.:||..:.      .|:.|:|||.:|..:|
Frog   109 GSAHAGIPQTAAYYPYEHTLSQYQYDRYGTMDGSTRRKNATRE------TTSTLKAWLQEHRKNP 167

  Fly   392 YPSEDQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVYTP 438
            ||::.:|..||..|.:|:.||:.||.|||||     :.:.|:..:.|
Frog   168 YPTKGEKIMLAIITKMTLTQVSTWFANARRR-----LKKENKMTWPP 209

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hth	NP_476576.1	Meis_PKNOX_N	127..211	CDD:406806
hth	NP_476576.1	Homeobox_KN	383..422	CDD:399131	18/38 (47%)
irx4	NP_001263621.1	Homeobox_KN	159..198	CDD:368670	18/38 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	203..236		2/7 (29%)
		IRO	356..369	CDD:214716
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910