Protein Alignment Cyp12e1 and cyp27a1.2

DIOPT Version :9

• Sequence 1: NP_650003.4
• Gene: Cyp12e1 / 41272
• FlyBaseID: FBgn0037817
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: XP_001334004.3
• Gene: cyp27a1.2 / 795106
• ZFINID: ZDB-GENE-081104-511
• Length: 522
• Species: Danio rerio
• Alignment Length: 536
• Identity: 145/536 - (27%)
• Similarity: 250/536 - (46%)
• Gaps: 78/536 - (14%)

  Fly    21 RGLAQKATAVNL------EEAKPYADIPGPSKLQLIRAFLPGGLYKNLPVHEMFLDMNRQYGSIF 79
            |..|..|.|.::      .:.|..||:|......::...|..| |.| .|||:.|...:.||.::
Zfish    28 RSAAGNAAAASVSVQDGHRKLKTEADLPEIKIFTMLYQMLFKG-YLN-SVHELQLYQKQVYGPLW 90

  Fly    80 RMP-------SVAGTDLVLTMNPQDYEVIFRNEGQYPYR---------RSFEVMDYFKRVHRREV 128
            ::.       |::..:|:        |.:.|.:.:||.|         |....:.|
Zfish    91 KINAGNLQGISISSVELL--------EELLRKDEKYPCRGYMTLWTEHRDLRGISY--------- 138

  Fly   129 FDGYDGLTSGNGPAWGKMRTAVNPILLQPRNAKLYMTNLVQVSDEFLERIRIIRD-PVTQEMPDD 192
                 |..:..|..|.|:|..:|..:|.|:::..|...:..|..:|::||..:|: ..|.::..:
Zfish   139 -----GPFTEEGEKWYKLRAVLNKRMLHPKDSVQYGDVVNAVITDFIKRIYYLREMSPTGDLVSN 198

  Fly   193 FAVDIRHLVIESICSVALNTHLGLLGEQRNNKDIQKLVLALQDVVELGFQLDIMPAFW--KYLPM 255
            ...::....:|.|.|:...|.:|.| |:....:.||.:..:..:......:.::|. |  ||.|.
Zfish   199 LTNELYRFSLEGIASILFETRIGCL-EKEIPAETQKFINFIAQMFTYSMHVALLPN-WTRKYFPF 261

  Fly   256 PNFKKLMRSLDTITDFCYFHIGNALKRIEEDAKAGTLNEIGLE--TSLLE--KLARFDRQTAVII 316
              ::|.:...|.|..|....|...::.|::  :..|..::..|  |.||.  |::|.|...:|
Zfish   262 --WQKYIDGWDGIFKFGTKMIDMKMEAIQK--RVDTNQDVAGEYLTYLLSNGKISRKDVYGSV-- 320

  Fly   317 AMDLLFAGADPTLVTLGGILFSLSKSPDKQARLLEEIRGILPNKDSSL-TIENMRNLPYLRACIK 380
             .:||.||.|.|..|:...|:.|||.|:.|..|.:|:..:|  ||..: |.|.:.::|:|:|.||
Zfish   321 -SELLLAGVDSTSNTMLWALYLLSKDPEAQETLYQEVTKVL--KDDRIPTAEEVNSMPFLKAVIK 382

  Fly   381 EGIRMYPIGPGTLRRMPH-DVVLSGYRVVAGTDVGIAANYQMANMEQFVPKVREFIPERWLRDES 444
            |.:|:||:.|...|.:.. :||:..|.....|...: .:|.::..|:..|:.::|.|||||||
Zfish   383 ETLRLYPVVPVNSRLIAETEVVIGEYFFPKKTTFTL-CHYVISRDEKVFPEPQKFKPERWLRD-- 444

  Fly   445 NSHLVGET-ATPFMYLPFGFGPRSCAGKRIVDMMLEIAISRLVRNFKIGFDYPIENAFKAQF--F 506
                 |.| ..||..:|||||.|:|.|:||.::.:.:|::||::.|::..| |.....||.|  .
Zfish   445 -----GRTRPNPFGSIPFGFGVRACVGRRIAELEMHLALARLIKLFEMRPD-PTVGEVKANFRSV 503

  Fly   507 VQPNIPFKFKFIERNE 522
            :.||......|:||.:
Zfish   504 LVPNKKVNLHFVERQK 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12e1	NP_650003.4	p450	63..517	CDD:299894	130/481 (27%)
cyp27a1.2	XP_001334004.3	p450	66..505	CDD:278495	132/482 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.830